Expression of retinoic acid receptor genes in keratinizing front of skin.

FEBS Letters
S NojiS Taniguchi

Abstract

We found, by an in situ hybridization method with riboprobes synthesized from human cDNA of the retinoic acid receptor (RAR), that the RAR genes (predominantly gamma-subtype) are intensively expressed in the epidermis of normal and psoriasic human skins, and also in keratinizing fronts of 4-day-old mouse skins, nail matrices and hair follicles. Thus, target cells of retinoic acid in the skins are concluded to be keratinocytes, which is quite consistent with the fact that retinoic acid regulates keratinization of epidermis in vivo and also modulates expression of the keratin gene in vitro.

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Citations

Oct 24, 2013·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·K FritzM Onder
Dec 1, 1990·The Journal of Cell Biology·E Fuchs
Jan 1, 1997·Journal of Periodontal Research·T C HartW A Soskolne
Dec 1, 1990·Current Opinion in Cell Biology·E Fuchs
Dec 5, 2012·Biochemical and Biophysical Research Communications·Hideaki NaoeShinji Kuninaka
Aug 1, 1997·The British Journal of Oral & Maxillofacial Surgery·J A Sherman, M Partridge
Dec 1, 1992·The Journal of Investigative Dermatology·C BuschU Eriksson
Jun 1, 1994·The Journal of Investigative Dermatology·N AzumaA Ohshima

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