PMID: 18709947Aug 20, 2008Paper

Expression of rhodopsin for experimental myopia of form-deprivation and defocus in guinea pig

Yan ke xue bao = Eye science
Min HuRen-yuan Chu

Abstract

To investigate the rhodopsin expression in form-deprived and defocus myopia in guinea pig and study the relationship between the rhodopsin expression and experimental myopia. Fourty guinea pigs were randomized into the form-deprived group and the defocus group (n = 20). Guinea pigs in the form-deprived group wore a diffused (rigid glass-permeable contact lens (RGP) on one eye since one week after birth. Those in defocus group wore a -4 D RGP on one eye. The contralateral eyes were left as control. Refraction, axial length and depth of vitreous cavity were measured after 1 and 2 weeks respectively. Retina were dissected at 10-12 o'clock in the morning. The level of rhodopsin and its mRNA were observed through Western-blot and real-time PCR respectively. There is no difference between form-deprived group, defocus group and control groups (except refraction in form-deprived group). One week later, there is no difference between the form-deprived group, the defocus group and the control groups (except refraction in form-deprived group). Two weeks later, eyes in the form-deprived group and the defocus group became myopic. Its axial length lengthened and depth of vitreous cavity appeared deep. The form-deprived groups showed an incre...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology
Min HuRen-yuan Chu
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology
Jin LiCui-di DA
Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)
Patricia GallegoJesús Merayo-Lloves
© 2022 Meta ULC. All rights reserved