Expression of RON Proto-oncogene in Renal Oncocytoma and Chromophobe Renal Cell Carcinoma

The American Journal of Surgical Pathology
Kurt T PattonXiming J Yang

Abstract

Recently, it was reported that RON proto-oncogene, encoding a receptor tyrosine kinase, was strongly expressed in renal oncocytomas but not in any renal cell carcinomas, including 5 chromophobe renal cell carcinomas, which morphologically resemble oncocytomas. To determine its diagnostic value, we studied Ron protein expression by immunohistochemistry in a larger number of renal cell neoplasms with emphasis on chromophobe renal cell carcinomas. Tissue microarrays containing 141 renal cell neoplasms, including 55 oncocytomas and 52 chromophobe renal cell carcinomas, were constructed. In addition, conventional sections from 15 cases of oncocytoma and 5 cases of chromophobe renal cell carcinoma were analyzed. Immunohistochemistry was carried out with a monoclonal mouse anti-human Ron-alpha antibody. Staining intensity was scored on a 0 to 3 scale. Ninety-nine percent of oncocytomas (69 of 70) and 96% of chromophobe renal cell carcinomas (55 of 57) showed moderate to strong, diffuse cytoplasmic Ron immunoreactivity with intensities > or =2, while only 17% of other renal cell carcinoma subtypes stained with intensities > or =2. Our study indicates that Ron immunostaining cannot be used to distinguish oncocytoma from chromophobe rena...Continue Reading

References

Aug 1, 1988·The Journal of Pathology·W ThoenesS Werner
Sep 1, 1995·The Journal of Urology·T B CrottyM M Lieber
Jul 22, 1998·Oncogene·P MaggioraP M Comoglio
Feb 22, 2002·Journal of the American Society of Nephrology : JASN·Teresa RampinoAntonio Dal Canton
Feb 23, 2002·The American Journal of Surgical Pathology·Mahul B AminMani Menon
May 27, 2003·The American Journal of Surgical Pathology·Teresa RampinoAntonio Dal Canton

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Citations

Aug 28, 2007·World Journal of Urology·Rosamonde E BanksPeter J Selby
Dec 18, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Laleh EhsaniAdeboye O Osunkoya
Apr 29, 2005·The Journal of Molecular Diagnostics : JMD·Audrey N SchuetzAndrew N Young
Mar 16, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Saba YasirMerce Jorda
Feb 18, 2005·American Journal of Clinical Pathology·Shang-Tian ChuangXiming J Yang
Jun 7, 2006·American Journal of Clinical Pathology·Brian P AdleyXiming J Yang
Nov 27, 2014·Archives of Pathology & Laboratory Medicine·Myra L WilkersonLiang Cheng
Jul 2, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Maria V Yusenko
Aug 2, 2007·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Yuchun TangZhen Huang
Mar 4, 2006·Seminars in Diagnostic Pathology·Brian F Skinnider, Mahul B Amin
Apr 26, 2005·Clinics in Laboratory Medicine·Neil A Abrahams, Pheroze Tamboli
Nov 5, 2016·Journal of Cancer Research and Clinical Oncology·Omid ZareiSiavoush Dastmalchi
Mar 28, 2006·Human Pathology·Fan LinUNKNOWN French Kidney Cancer Study Group
Mar 26, 2005·Human Pathology·Lei HuoXiming J Yang
Dec 25, 2007·Advances in Anatomic Pathology·Andrew N YoungMahul B Amin
Feb 6, 2017·Investigational New Drugs·Patricia M LoRussoE Gabriela Chiorean

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