Expression of Ror2 Associated with Fibrosis of the Submandibular Gland

Cell Structure and Function
Daiki TakahashiMichiru Nishita

Abstract

The submandibular gland (SMG) is one of the major salivary glands that play important roles for variety of physiological functions, such as digestion of foods, prevention of infection, and lubrication of the mouth. Dysfunction of the SMG, often associated with a salivary inflammation, adversely influences a person's quality of life. However, the mechanism underlying inflammation-driven dysfunction of the SMG is largely unknown. Here, we used a mouse model in which the main excretory duct of the SMG is ligated unilaterally to induce inflammation of the gland and examined the expression of Wnt5a, Ror1 and Ror2 genes, encoding Wnt5a ligand and its cognate receptors, which have been implicated in tissue damage or inflammatory responses in variety of tissues. We show that expression levels of Ror1, Ror2, and Wnt5a are increased in the ligated SMG undergoing interstitial fibrosis, which is accompanied by robust expression of fibrosis-associated genes, such as TGF-β1, TNF-α, IL-1β, and MMP-2. Increased immunostaining signal of Ror2 was detected in the fibrotic tissues with abundant accumulation of fibroblasts and collagen fibers in the ligated SMG, suggesting that Ror2-mediated signaling might be activated in response to tissue damage...Continue Reading

References

Apr 8, 1998·Current Opinion in Genetics & Development·K Willert, R Nusse
Jan 13, 2006·Kidney International·Youhua Liu
Mar 3, 2007·The Journal of Clinical Investigation·Thomas A Wynn
Aug 2, 2013·American Journal of Physiology. Cell Physiology·Ariane Mallat, Sophie Lotersztajn

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Citations

May 31, 2018·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Takeshi SajiYasuhiro Minami
Dec 4, 2020·International Journal of Molecular Sciences·Xianglan ZhangEunae Sandra Cho
Jun 23, 2021·Journal of the American Heart Association·Nicholas W ChavkinKenneth Walsh
Sep 22, 2020·The Korean Journal of Internal Medicine·Ji-Hye SonChoon-Sik Park

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