PMID: 8950039Nov 1, 1996Paper

Expression of S-adenosylmethionine synthetase isozyme genes in regenerating rat liver after partial hepatectomy

Biochemistry and Molecular Biology International
S HorikawaT Sugiyama

Abstract

Mammalian S-adenosylmethionine (AdoMet) synthetase exists as two isozymes, liver-type and non-hepatic-type enzymes. To investigate the possible role of AdoMet synthetase in proliferating cells, we have examined the expression of these two isozyme genes in regenerating rat liver after partial hepatectomy using Northern blot analysis. In normal adult rat liver the non-hepatic-type isozyme mRNA was not detectable, however, when partial hepatectomy was performed, there was an obvious appearance of the non-hepatic-type enzyme mRNA after operation. The levels of non-hepatic-type isozyme mRNA was peaked at 4h and maintained the level at least till 8 h after operation, then decreased. In addition, the liver-type AdoMet synthetase gene expression was also induced by partial hepatectomy with similar time course. These results indicate that these two AdoMet synthetase isozymes may play an important role during the prereplicative phase which precedes DNA synthesis.

Citations

Mar 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Enrique SantamariaFernando J Corrales
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Z Z HuangS C Lu
Apr 15, 2016·World Journal of Gastroenterology : WJG·Sonia Amelia Lozano-SepulvedaAna Maria Rivas-Estilla

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