Expression of selected genes in preterm premature rupture of fetal membranes

Acta Obstetricia Et Gynecologica Scandinavica
Paweł KućTadeusz Laudański

Abstract

To analyse the expression of 15 genes encoding receptors and enzymes associated with the molecular mechanism of the tocolytic drugs atosiban (oxytocin receptor antagonist), nifedipine (calcium channel blocker) and celecoxib (selective cyclo-oxygenase-2 inhibitor) in preterm labor patients with premature rupture of fetal membranes in relation to symptoms of intrauterine infection and preterm labor risk factors. Experimental molecular study. Tertiary obstetric care center. Myometrial samples were obtained during cesarean sections from 35 patients who delivered preterm with unverified symptoms of intrauterine infection, 35 patients who delivered preterm without symptoms of intrauterine infection and 90 women who delivered at term. The Micro Fluidic Profiling Card analytic system was used to evaluate mRNA expression of the genes of interest. The relative quantification values for mRNA expression. The median oxytocin receptor and cyclo-oxygenase-2 mRNA expression in preterm patients with clinical symptoms of intrauterine infection was significantly higher than in preterm patients without symptoms. The median mRNA expression of β(1) , β(3) and β(4) subunits of the L-type calcium channel and prostaglandin E(2) receptor was significant...Continue Reading

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Citations

Dec 6, 2014·Mediators of Inflammation·Piotr LaudanskiRadoslaw Charkiewicz
May 31, 2014·Mediators of Inflammation·Piotr LaudanskiTadeusz Laudanski
Jan 22, 2019·Canadian Journal of Physiology and Pharmacology·Daniela UrregoDonna M Slater
Apr 20, 2018·Mediators of Inflammation·Barbara LizewskaPiotr Laudanski
Jul 13, 2021·Frontiers in Medicine·Giovanni MonniFederica Murgia
Aug 7, 2021·Metabolites·Young-Ah YouYoung-Ju Kim

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