PMID: 16501837Feb 28, 2006Paper

Expression of serine protease matriptase in renal cell carcinoma: correlation of tissue microarray immunohistochemical expression analysis results with clinicopathological parameters

International Journal of Surgical Pathology
Jong-Shiaw JinYeh-Feng Lin

Abstract

Serine protease matriptase (matriptase) cleaves and activates proteins implicated in the progression of cancer and represents a potential therapeutic target. Immunohistochemical analysis of matriptase was performed in tissue microarrays of 168 renal cell carcinomas (RCCs). All subtypes of RCC showed significant immunohistochemical expression of matriptase. In contrast, no expression occurred in areas of RCC with sarcomatous differentiation (SRCC) and in normal collecting tubules. The matriptase scores were significantly higher in papillary RCC (341+/-28) and clear cell RCC with granular cell differentiation (GRCC; 324+/-27) than in other histologic subtypes of RCC. In GRCC, matriptase scores were correlated with TNM staging and nuclear grading. Matriptase was overexpressed in all subtypes of RCC, and matriptase scores could distinguish between conventional clear cell RCC, GRCC, and SRCC.

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Citations

Feb 11, 2010·Cancer Research·Molly R DarraghCharles S Craik
Nov 20, 2013·Virchows Archiv : an International Journal of Pathology·Sang Yun HaSeok-Hyung Kim
Dec 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Aaron M LeBeauCharles S Craik
Jan 1, 2014·Journal of Proteomics·Maria FrantziAxel S Merseburger
Feb 27, 2009·The Journal of Investigative Dermatology·Georgeta BochevaMartin Steinhoff
Apr 15, 2016·Biological Chemistry·Andrew S MurrayKarin List
Feb 8, 2019·Pathology International·Toshihide KomatsubaraNoriyoshi Fukushima

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