PMID: 2122966Jan 1, 1990Paper

Expression of serum IL-2, IL-2R, and CD8 levels during hyposensitization in house-dust-sensitive asthmatics

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
L C TsaiS J Tsai

Abstract

In this study, we used the enzyme-linked immunosorbent assay (ELISA) to evaluate the changes of serum interleukin-2 (IL-2), interleukin-2 receptor (IL-2R), and suppressor/cytotoxicity factor (CD8) in house dust-sensitive asthmatic children during hyposensitization. Patients before immunotherapy presented significantly higher serum levels of IL-2 and IL-2R than normal subjects (p less than 0.001), but these levels became normal after three years of hyposensitization. No significant difference of serum CD8 level was noted between pretreated patients and normal controls. Although the serum CD8 level in treated patients also decreased after three years of immunotherapy, this decrease was not significant compared with the pretreated patients (p greater than 0.05). This study suggests that serum IL-2 and IL-2R markers might be helpful in analyzing allergic states associated with immune activation and in evaluating the therapeutic effects of hyposensitization.

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Citations

Jul 27, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Iwona StelmachPiotr Kuna
Sep 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Y OhashiM Hayashi
Apr 6, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R B Tang, S J Chen
Aug 1, 1995·Acta Paediatrica Japonica; Overseas Edition·M NabetaniT Kishimoto
Aug 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H P van BeverW J Stevens
May 1, 2012·International Immunopharmacology·Zeynep MatAndrea Koch
Oct 2, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H P van BeverW J Stevens
May 1, 1993·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M M MoensW J Stevens
Feb 6, 2020·Journal of the Chinese Medical Association : JCMA·Ren-Bin Tang
Sep 14, 2004·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Iwona StelmachPiotr Kuna

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