Expression of sialyl-Tn in breast cancer. Correlation with prognostic parameters

Pathology, Research and Practice
R SoaresF Schmitt

Abstract

To investigate the expression of a simple mucin-type carbohydrate antigen (Sialyl-Tn/STn) and its putative relationship with established or potentially useful clinico-pathologic prognostic parameters in breast cancer, we studied forty-six cases of invasive breast carcinoma in formalin-fixed, paraffin-embedded tissue sections. STn antigen was detected by the HB-STn antibody using an avidin-biotin-peroxidase method. The parameters studied were tumour size, histologic grade, nodal status, proliferative index (with MIB-1), ER expression, ploidy, c-erbB-2 and p53 expression. STn expression was observed in 18 cases (39%) of breast cancer. The expression of STn was associated with axillary node metastasis, ER negativity and c-erbB-2 expression. A tendency towards an association between STn immunoreactivity and high histologic grade was also found. No correlation was observed between STn immunoreactivity and age, tumour size, proliferative index, ploidy and p53 expression. We conclude that the detection of STn immunoreactivity may be useful for predicting the likelihood of lymph node metastasis and that the outcome of patients with breast cancer should be further investigated in order to find whether or not the data of the present stud...Continue Reading

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Citations

Mar 17, 2005·Breast Cancer Research and Treatment·Sylvain JulienPhilippe Delannoy
Mar 30, 1999·The Journal of Thoracic and Cardiovascular Surgery·T A D'AmicoD H Harpole
May 12, 2001·The Breast Journal·Raquel SoaresFernando Carlos Schmitt
Jun 17, 2010·Breast Cancer Research : BCR·Aurélie CazetPhilippe Delannoy
Aug 14, 2015·Biomolecules·Liliana R LoureiroPaula A Videira
Dec 18, 2013·Proteomics·Maja N ChristiansenNicolle H Packer
Apr 20, 2016·Nature Reviews. Urology·Jennifer MunkleyDavid J Elliott
Jan 1, 2012·Biomolecules·Sylvain JulienPhilippe Delannoy
Jul 22, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuliang JiangTongzhong Ju
Apr 2, 2009·Biological Chemistry·Aurélie CazetPhilippe Delannoy
Jan 15, 2010·Biomarker Insights·Hongjun Jin, Richard C Zangar
Sep 17, 2019·Expert Opinion on Therapeutic Targets·Anne Bärenwaldt, Heinz Läubli
May 7, 2020·Journal of Experimental & Clinical Cancer Research : CR·Liliana R LoureiroClaudia Arndt
Nov 13, 2020·Cancer Immunology Research·Wen-Der LinAlice L Yu
Feb 23, 2000·Molecular Cell Biology Research Communications : MCBRC·J P PeyratP Delannoy
Mar 17, 2010·Carbohydrate Research·Aurélie CazetPhilippe Delannoy

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