PMID: 20625653Jul 14, 2010Paper

Expression of SMAD proteins, TGF-beta/activin signaling mediators, in human thyroid tissues

Arquivos brasileiros de endocrinologia e metabologia
S E MatsuoE T Kimura

Abstract

To investigate the expression of SMAD proteins in human thyroid tissues since the inactivation of TGF-beta/activin signaling components is reported in several types of cancer. Phosphorylated SMAD 2 and SMAD3 (pSMAD2/3) associated with the SMAD4 induce the signal transduction generated by TGF-beta and activin, while SMAD7 inhibits this intracellular signaling. Although TGF-beta and activin exert antiproliferative roles in thyroid follicular cells, thyroid tumors express high levels of these proteins. The protein expression of SMADs was evaluated in multinodular goiter, follicular adenoma, papillary and follicular carcinomas by immunohistochemistry. The expression of pSMAD2/3, SMAD4 and SMAD7 was observed in both benign and malignant thyroid tumors. Although pSMAD2/3, SMAD4 and SMAD7 exhibited high cytoplasmic staining in carcinomas, the nuclear staining of pSMAD2/3 was not different between benign and malignant lesions. The finding of SMADs expression in thyroid cells and the presence of pSMAD2/3 and SMAD4 proteins in the nucleus of tumor cells indicates propagation of TGF-beta/activin signaling. However, the high expression of the inhibitory SMAD7, mostly in malignant tumors, could contribute to the attenuation of the SMADs ant...Continue Reading

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Citations

Oct 16, 2013·Endocrine Pathology·Celina Montemayor-GarciaRicardo V Lloyd
Jul 25, 2012·Thyroid : Official Journal of the American Thyroid Association·Mírian RomittiAna Luiza Maia
Sep 4, 2013·Thyroid : Official Journal of the American Thyroid Association·Cesar Seigi Fuziwara, Edna Teruko Kimura
Apr 2, 2013·Translational Oncology·Alex Shimura YamashitaEdna Teruko Kimura
Jun 17, 2015·Experimental and Molecular Pathology·Aleksandra NikolicIvan Paunovic
Jan 1, 2014·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Matthew D BraceRobert D Hart
Dec 25, 2016·Molecular and Cellular Endocrinology·Cesar Seigi Fuziwara, Edna Teruko Kimura
Dec 16, 2017·Journal of Cellular Biochemistry·Faiza Abdul RashidAmmad Ahmad Farooqi
Apr 25, 2012·Virchows Archiv : an International Journal of Pathology·C EloyM Sobrinho-Simões
Jul 16, 2011·Journal of Thyroid Research·Gabriella MincioneAnna Coppa
Mar 19, 2019·Frontiers in Endocrinology·Cesar Seigi FuziwaraEdna Teruko Kimura
Jan 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sheila C AraujoKathia M Honorio
Sep 5, 2019·Archives of Endocrinology and Metabolism·Cesar Seigi FuziwaraEdna Teruko Kimura
Dec 22, 2017·Journal of Cellular and Molecular Medicine·Guillermo PousadaDiana Valverde
Sep 17, 2020·The Journal of Clinical Endocrinology and Metabolism·Jingtai ZhiMing Gao
Feb 13, 2021·Acta Tropica·Andressa Barban do PatrocínioVanderlei Rodrigues

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