PMID: 9431536Feb 12, 1998Paper

Expression of smooth-muscle actin in cultured cells from human plasmacytoid myoepithelioma

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
R G JaegerV C de Araújo

Abstract

The definition of plasmacytoid myoepithelioma, a neoplasm exhibiting myoepithelial differentiation, has been recently questioned. To better understand the histogenesis of this neoplasm, we searched for myoepithelial markers in histologic sections of plasmacytoid myoepithelioma and in a cell line (M1) derived from this same neoplasm. Expression of vimentin, pan-keratin (AE-3) and smooth-muscle actin was studied by immunohistochemistry in paraffin-embedded tissue and by immunofluorescence in M1 cells. Plasmacytoid myoepithelioma tumor sections showed vimentin and AE-3 reactivity, but evidence of smooth-muscle actin was not seen. The cell line derived from this tumor also produced vimentin and cytokeratin. In addition, all cultured cells expressed smooth-muscle actin. We demonstrated that cells derived from a case of plasmacytoid myoepithelioma appear to show full myoepithelial differentiation in vitro. Thus, they are myoepithelial-like cells in nature. The lack of myogenous differentiation in vivo could be due to an inhibitory process mediated by the extracellular matrix.

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Citations

Apr 3, 2007·International Journal of Paediatric Dentistry·Danyel Elias da Cruz PerezLuiz Paulo Kowalski
Apr 2, 2008·Matrix Biology : Journal of the International Society for Matrix Biology·Letícia N Gama-de-SouzaRuy G Jaeger
Apr 20, 2004·Advances in Anatomic Pathology·Adnan T Savera, Richard J Zarbo
Mar 14, 2008·International Journal of Experimental Pathology·Ruy G JaegerVanessa M Freitas

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