Expression of Sox-9 in metastatic melanoma--a potential diagnostic pitfall

The American Journal of Dermatopathology
Priya RaoV G Prieto

Abstract

SOX-9 was originally identified as a master regulator gene that plays a role in the differentiation of mesenchymal cells to chondrocytes. Since then, SOX-9 has been implicated in neural crest development and has emerged as a transcriptional regulator of melanogenesis. Because the role of immunohistochemical detection of SOX-9 in the routine diagnosis of melanoma has not been previously described, we attempted to elucidate the spectrum and labeling characteristics of this antibody in a large cohort of patients with metastatic melanoma. We analyzed the expression of SOX-9 on sections of metastatic melanoma in a tissue microarray and compared the expression of this marker with 3 commonly used melanocytic markers (MART-1, HMB-45 antigen, and S-100 protein). SOX-9 expression was noted in 52 of the 62 cases (83.9%). In comparison, HMB-45 was positive in 53 of the 62 cases (85.5%), MART-1 was positive in 59 of the 62 cases (95.1%), and S-100 protein was positive in 57 of the 62 cases (95%). Interestingly, there were 5 tumors that were negative for 2 or more markers while being positive for SOX-9. Furthermore, 3 of these were negative for all markers except for SOX-9. Our study illustrates that SOX-9 is expressed in a high percentage o...Continue Reading

References

Apr 1, 1997·Molecular and Cellular Biology·V LefebvreB de Crombrugghe
May 6, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·V Lefebvre, B de Crombrugghe
Feb 26, 1999·Nucleic Acids Research·M Wegner
Mar 12, 2005·Pigment Cell Research·Michael Wegner
May 18, 2005·Experimental Cell Research·Anthony L CookRichard A Sturm
Jun 23, 2006·Journal of Neuro-oncology·U Kordes, C Hagel
Mar 13, 2008·Journal of Cutaneous Pathology·Valérie P I VidalAndreas Schedl
Jul 19, 2008·The American Journal of Surgical Pathology·Daisuke NonakaBrian P Rubin
Oct 17, 2008·The Journal of Investigative Dermatology·Anna FlammigerCarola Berking
Nov 21, 2008·American Journal of Clinical Pathology·Bingjian LüMaode Lai

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Citations

May 7, 2010·Pigment Cell & Melanoma Research·Melissa L HarrisWilliam J Pavan
Jan 17, 2012·Cancer Research·Ander MatheuRobin Lovell-Badge
Jan 18, 2011·Trends in Molecular Medicine·James PritchettKaren Piper Hanley
Jul 29, 2011·International Journal of Cancer. Journal International Du Cancer·Oscar AlcazarPierre Triozzi
Mar 20, 2021·BMC Endocrine Disorders·Farzad Izak ShirianMasoumeh Tavakoli-Yaraki
Feb 16, 2012·International Journal of Surgical Pathology·Kristopher M McKayVictor G Prieto

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