PMID: 11340100May 8, 2001Paper

Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice

The Journal of Nutrition
M D KnutsonMarianne Wessling-Resnick

Abstract

Hfe knockout (-/-) mice recapitulate many of the biochemical abnormalities of hereditary hemochromatosis (HH), but the molecular mechanisms involved in the etiology of iron overload in HH remain poorly understood. It was found previously that livers of patients with HH contained 5-fold higher SFT (stimulator of Fe transport) mRNA levels relative to subjects without HH. Because this observation suggests a possible role for SFT in HH, we investigated SFT mRNA expression in Hfe(-/-) mice. The 4- and 10-wk-old Hfe(-/-) mice do not have elevated levels of hepatic SFT transcripts relative to age-matched Hfe(+/+) mice, despite having 2.2- and 3.3-fold greater hepatic nonheme iron concentrations, respectively. Northern blot analyses of various mouse tissues revealed that SFT is widely expressed. The novel observation that SFT transcripts are abundant in brain prompted a comparison of SFT transcript levels and nonheme iron levels in the brains of Hfe(+/+) and Hfe(-/-) mice. Neither SFT mRNA levels nor nonheme iron levels differed between groups. Further comparisons of Hfe(-/-) and Hfe(+/+) mouse tissues revealed no significant differences in SFT mRNA levels in duodenum, the site of increased iron absorption in HH. Important distinctions...Continue Reading

References

Jan 1, 1991·The American Journal of the Medical Sciences·H L Bonkovsky
Jan 1, 1988·Annals of the New York Academy of Sciences·J KaplanS Bernstein
Sep 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R SciotV J Desmet
Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M L BassettL W Powell
Aug 1, 1997·Nature Genetics·J V Gray, K J Johnson
Dec 31, 1997·The Journal of Cell Biology·J A GutierrezM Wessling-Resnick
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·J N FederR C Schatzman
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·X Y ZhouW S Sly
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·A WaheedW S Sly
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·R E FlemingW S Sly
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·S BahramK Schümann
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·R E FlemingW S Sly
Mar 23, 2000·Journal of Hepatology·L W PowellT R Yapp
Apr 25, 2000·Journal of Neuroscience Research·E A MaleckiJ R Connor
May 3, 2000·The Journal of Clinical Investigation·J E LevyN C Andrews

❮ Previous
Next ❯

Citations

Apr 24, 2003·Neurotoxicity Research·D. BergO. Riess
Apr 24, 2004·Annals of the New York Academy of Sciences·Torben Moos, Evan H Morgan
Jul 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·John D RyanJohn Crowe
Mar 30, 2010·Journal of Neurochemistry·Daniel Johnstone, Elizabeth A Milward
May 13, 2004·Journal of Neuroscience Research·Mitchell KnutsonMarianne Wessling-Resnick
Mar 7, 2014·Metallomics : Integrated Biometal Science·Katharina FernsebnerBernhard Michalke
Jun 6, 2003·American Journal of Physiology. Renal Physiology·Jun YangJonathan Barasch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.