Expression of store-operated channel components in prostate cancer: the prognostic paradox

Human Pathology
Marie-Aimée Perrouin VerbeGaelle Fromont

Abstract

In vitro studies in prostate cancer (PCa) cell lines have suggested a key and complex role of the store-operated channels (SOCs) in major cancer hallmarks, including proliferation, apoptosis, and migration. In the present study, we investigated in vivo the expression of the SOC components transient receptor potential canonical (TRPC) 1, TRPC4, Orai1, and stromal interaction molecule 1 (STIM1), during all stages of PCa progression, and evaluated their prognostic impact in clinically localized cancer (CLC). The expressions of TRPC1, TRPC4, Orai1, STIM1, and the androgen receptor and the proliferation marker Ki-67 were evaluated by immunohistochemistry on tissue microarrays containing samples of normal prostate tissues (n=91), prostatic intraepithelial neoplasia (n=61), CLC surgically treated (n=238), and castration-resistant prostate cancer (CRPC; n=45). All markers significantly increased in CLC compared with normal tissues and (for Orai1 and STIM1) in advanced pT3 tumors compared with pT2. In contrast, their expression decreased in CRPC, particularly for Orai1. In CLC, staining for TRPC1, Orai1 and STIM1 correlated with androgen receptor expression, and TRPC1 status was associated with lower proliferation and longer recurrence-...Continue Reading

References

Dec 1, 2009·FEBS Letters·Kyu Pil LeeShmuel Muallem
Jul 23, 2011·Nature Reviews. Cancer·Natalia PrevarskayaYaroslav Shuba
Mar 13, 2014·Biochimica Et Biophysica Acta·Maxime GuéguinouMarie Potier-Cartereau
Sep 2, 2014·The Prostate·Michael TarisGaelle Fromont

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Citations

Apr 8, 2017·Nature Reviews. Cancer·Gregory R MonteithSarah J Roberts-Thomson
Jan 1, 2017·Current Molecular Biology Reports·Sven KappelAnna Borgström
Sep 24, 2020·Annual Review of Pharmacology and Toxicology·Daniel BakowskiAnant B Parekh
Jan 1, 2020·Expert Review of Precision Medicine and Drug Development·Husain Yar KhanAsfarSohail Azmi
Jul 30, 2019·Molecular Pharmaceutics·Diane BressandAyache Bouakaz

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