Expression of stromal-derived factor-1 is decreased by IL-1 and TNF and in dermal wound healing

The Journal of Immunology : Official Journal of the American Association of Immunologists
E R FedykT A Springer

Abstract

Stromal-derived factor-1 (SDF-1) is a CXC chemokine that is believed to be constitutively expressed by stromal cells of numerous tissues. In this report, we demonstrate that dermal fibroblasts and vessels of noninflamed tissues express SDF-1. Unexpectedly, we found that expression of SDF-1 is regulated by inflammation. Expression of SDF-1 by primary cultures of human gingival fibroblasts is potently inhibited by activated macrophages via secretion of IL-1alpha and TNF-alpha. Levels of SDF-1 mRNA also decrease in acutely inflamed mouse dermal wounds. We propose that SDF-1 functions as a homeostatic regulator of tissue remodeling, whose expression stabilizes existing dermal architecture.

References

Mar 1, 1994·Journal of Leukocyte Biology·C SunderkötterC Sorg
May 1, 1995·Journal of Neuroimmunology·R GodiskaP W Gray
Nov 10, 1995·The Journal of Biological Chemistry·R M StrieterD Marriott
Sep 1, 1996·The Journal of Experimental Medicine·C C BleulT A Springer
Nov 19, 1997·Journal of Leukocyte Biology·D A ArenbergR M Strieter
Jan 24, 1998·Biochemical and Biophysical Research Communications·M V VolinP F Davies
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·Q MaT A Springer

❮ Previous
Next ❯

Citations

Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·José L PablosFrancisco J García-Lázaro
Jan 7, 2004·The Journal of Experimental Medicine·Yoshihiro UedaGarnett Kelsoe
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·S John CurnowMike Salmon
Mar 27, 2007·The Journal of Urology·Lynn L WooRaymond R Rackley
May 6, 2008·Journal of Periodontology·Aaron M HavensRussell S Taichman
May 23, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Diego FrancoAntonio Caruz
Oct 7, 2010·The Journal of Biological Chemistry·Lisa A Madge, Michael J May
Dec 24, 2010·PloS One·Manoj M PillaiBeverly Torok-Storb
Nov 15, 2012·The Tohoku Journal of Experimental Medicine·Shou-Lin LiLi-Hong Feng
Jan 18, 2018·European Journal of Medical Research·Erich BünemannPeter Arne Gerber
Jun 17, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yang-Soo KimTheodore A Blaine
Oct 19, 2007·The British Journal of Dermatology·A ToksoyM Goebeler
Dec 20, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael B DwinellMartin F Kagnoff
Nov 21, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P J HohensinnerJ Wojta
Nov 17, 2007·Proceedings of the National Academy of Sciences of the United States of America·Norifumi IijimaAkiko Iwasaki
Jan 29, 2011·Inflammation·Hongkuan FanJames A Cook
Jun 19, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erin E McCandlessRobyn S Klein
Jun 15, 2012·The European Journal of Neuroscience·Annabelle Reaux-Le GoazigoStéphane Melik Parsadaniantz
Jun 8, 2010·Cell Transplantation·Hiroshi YagiMartin L Yarmush
Jan 13, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ewa K StuermerPaola Koenen
Oct 24, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Amirbahman RahimzadehAbolfazl Akbarzadeh
Dec 12, 2018·Stem Cell Research & Therapy·Ioannis ChristodoulouVassilis Zoumpourlis
Mar 5, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Kohei MiuraBosco M C Chan
Jul 5, 2003·Physiological Reviews·Sabine Werner, Richard Grose
Mar 25, 2004·Infection and Immunity·Nilda E RodriguezMary E Wilson
Apr 25, 2007·Cell and Tissue Research·Andrea T BadilloKenneth W Liechty
Oct 15, 2005·Bulletin of Experimental Biology and Medicine·D V DeminaI A Orlovskaya
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph M PettyBenjamin T Suratt
Jul 29, 2010·Journal of Cellular Physiology·Thomas P Lozito, Rocky S Tuan
Jun 7, 2013·Journal of Applied Oral Science : Revista FOB·Carla Renata SipertCarlos Ferreira Santos
Dec 17, 2008·The Journal of Cell Biology·Weiyi FengTatiana V Byzova
Aug 3, 2014·Inflammation·Mojgan Noroozi Karimabad, Gholamhossein Hassanshahi
Apr 5, 2016·Tissue Engineering and Regenerative Medicine·Nunggum JungKi-Sook Park

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

World Journal of Gastroenterology : WJG
Bao-Cheng ZhaoHui-Min Xu
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
P J HohensinnerJ Wojta
© 2021 Meta ULC. All rights reserved