PMID: 10218674Apr 28, 1999

Expression of stromelysin 3 in keratoarcanthoma and squamous cell carcinoma

The American Journal of Dermatopathology
P H AschB Cribier

Abstract

Stromelysin 3 (ST3) is a member of the metalloproteinase family, which is expressed in the skin during wound healing and in the stroma of basal cell carcinoma. A high level of expression of ST3 has been observed in carcinomas of poor prognosis. In benign tumors, though, ST3 is not expressed or is at a low level. We have immunohistochemically studied the expression of ST3 in 89 randomly selected cases of squamous cell carcinomas (SCCs), 104 of keratoacanthomas (KA), and 23 cases of metastatic SCC. Stromelysin 3 was expressed only by fibroblasts surrounding the tumors and not by epithelial cells. The proportion of tumors positively stained was 22% of KA, 47% of randomly selected SCC, and 70% of metastatic SCC. In areas of poorly demarcated neoplastic cells, a reinforcement of the staining was observed in the stroma. The intensity and dispersion of staining were used to determine the level of expression. There were significantly more SCC in the groups of high expression levels, and both parameters were significantly higher in SCC than in KA. Expression of ST3 in benign tumors is unusual. Its expression in the the stroma of keratoacanthomas can be related to the high tissue remodeling activity observed in these tumors. It also coul...Continue Reading

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Citations

Jun 3, 2009·Archives of Dermatological Research·Aikaterini MastorakiKiriaki Aroni
May 16, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tiina T KuivanenU Saarialho-Kere
Mar 25, 2008·The American Journal of Dermatopathology·Steven KossardCarolyn Choy
Jul 21, 2012·The American Journal of Dermatopathology·Marier Hernández-Pérez, Meera Mahalingam
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Feb 9, 2016·Journal of the American Academy of Dermatology·Bartlomiej Kwiek, Robert A Schwartz
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Jul 7, 2007·International Journal of Dermatology·Amel Karaa, Amor Khachemoune
Feb 10, 2006·Journal of Cutaneous Pathology·David S CassarinoR J Barr
Feb 27, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alka MahaleLaura Asnaghi
May 16, 2009·International Journal of Surgical Pathology·Aikaterini MastorakiKiriaki Aroni
Oct 18, 2015·Experimental Dermatology·Tobias GleichDaniel Hohl
Apr 25, 2006·Journal of Cutaneous Pathology·David S CassarinoR J Barr
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Related Concepts

Squamous Cell Carcinoma
Immunocytochemistry
Keratoacanthoma
Metalloendopeptidases
Randomization
Dermatologic Disorders
Malignant Neoplasm of Skin
Matrix Metalloproteinase 11

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