PMID: 9179921May 1, 1997Paper

Expression of stromelysin-3 in the human placenta and placental bed

Placenta
E MaquoiJ M Foidart

Abstract

Human placentation is mediated by fetal trophoblastic cells which penetrate into the decidualized uterine endometrium. Trophoblast invasion requires the precisely regulated secretion of specific proteinases able to degrade the endometrial basement membranes and extracellular matrix. To document further the involvement of these proteinases during human placentation, we evaluated in vivo the expression of stromelysin-3, a member of the metalloproteinase family, during the first and third trimesters of pregnancy, by means of immunohistochemistry, in situ hybridization and Northern blot analysis. Human extravillous trophoblasts invading the maternal decidua produced stromelysin-3 during both, the first and third trimesters of pregnancy, but to a lesser extent during the latter. In floating villi, stromelysin-3 expression was restricted to the syncytiotrophoblasts that line intervillous vascular spaces. In conclusion, stromelysin-3 is expressed by differentiated, non-proliferative villous and extravillous trophoblastic cells in early and late placental beds and villi, and its pattern of expression evolves during pregnancy. Our observations suggest that stromelysin-3 could play a role in human placentation.

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Citations

Mar 25, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T TeesaluD Talarico
Apr 30, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P Duc-GoiranF Ferré
Jul 27, 2006·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Fiona Lyall
Mar 26, 1999·Der Pathologe·H HerbstT Löning
May 1, 1997·Critical Reviews in Oncology/hematology·P BassetM C Rio
Apr 25, 2001·Biology of Reproduction·T E Curry, K G Osteen
Dec 14, 2004·Human Fertility : Journal of the British Fertility Society·Sheba Anin AninSiobhan Quenby
Sep 14, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·A TarradeD Evain-Brion

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