PMID: 9555006May 16, 1998Paper

Expression of substance P receptor in the substantia nigra

Brain Research. Molecular Brain Research
T FutamiS Furuya

Abstract

Since the substantia nigra receives abundant substance P innervations but lacks clear evidences about a presence of substance P receptors, expressions for mRNA and protein of substance P receptors were investigated in the rat to resolve this mismatch. Expression levels of substance P receptors mRNA in the substantia nigra pars compacta and reticulata were 37.7 and 24.1% of those in the striatum, respectively, by reverse transcription-polymerase chain reaction (RT-PCR). Substance P receptors mRNA was found in dopamine neurons of the substantia nigra pars compacta by single cell RT-PCR. Ca. 90% of dopamine neurons in the substantia nigra pars compacta were immunoreactive to anti-substance P receptor antibody in the colchicine treated rats. These are the first direct evidence for the existence of substance P receptors in dopamine neurons of the substantia nigra pars compacta.

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Citations

May 25, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Sep 13, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jarmo HietalaOlof Solin
Aug 12, 1999·European Journal of Pharmacology·A Saria
Sep 3, 2002·Neuroscience Research·Seloua Mounir, André Parent
Mar 11, 1999·Current Opinion in Neurobiology·M Hynes, A Rosenthal
Dec 12, 2001·British Journal of Pharmacology·A Lessard, R Couture
Jun 15, 2006·Journal of Neurochemistry·Krisztián A KovácsJean-René Cardinaux
Sep 7, 2006·Journal of Neuroscience Research·Georgia A BishopJames S King
Sep 18, 2007·The European Journal of Neuroscience·Qiao-Ling CuiLei Chen
Jun 14, 2017·Brain Structure & Function·Kazuko MizutaniFumino Fujiyama

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