PMID: 9662030Jul 14, 1998Paper

Expression of substrate-specific transporters encoded by Plasmodium falciparum in Xenopus laevis oocytes

Molecular and Biochemical Parasitology
J I PennySanjeev Krishna

Abstract

When the malarial parasite Plasmodium falciparum multiplies in erythrocytes it dramatically increases uptake of essential metabolic precursors (nucleosides, nucleobases and glucose) and export of lactic acid by undefined mechanisms. The first evidence is provided here, by a detailed study in Xenopus laevis oocytes, that several specific nutrient transporters are the product of P. falciparum genes. We report the expression of nucleoside, nucleobase, hexose and monocarboxylate transport systems in Xenopus oocytes when injected with mRNA isolated from asexual stages of developing P. falciparum parasites. Their properties are distinct from transport events occurring at the infected erythrocyte membrane or the electrophysiologically identified channel localised to the parasitophorous vacuolar membrane. These novel transporters are substrate-specific and stereoselective, and represent a key regulatory step in the acquisition and export of metabolites by intraerythrocytic P. falciparum.

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Citations

Sep 22, 2001·International Journal for Parasitology·S KrishnaC Woodrow
Jun 24, 2008·Eukaryotic Cell·Megan J DownieChoukri Ben Mamoun
Aug 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·C J WoodrowS Krishna
Jul 26, 2005·FEMS Microbiology Reviews·Harry P de KoningRichard J S Burchmore
Jul 22, 2008·Molecular and Biochemical Parasitology·Elvira T DerbyshireHenry M Staines
Mar 6, 1999·The Journal of Biological Chemistry·C J WoodrowS Krishna
Mar 29, 2001·Physiological Reviews·K Kirk
Sep 16, 2000·Molecular Membrane Biology·H de Koning, G Diallinas
Mar 18, 2008·Travel Medicine and Infectious Disease·Asha Parbhu PatelSanjeev Krishna

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