PMID: 9548182Apr 21, 1998Paper

Expression of syndecan-1 in human placenta and decidua

Placenta
V JokimaaL Anttila

Abstract

Syndecan-1 is a cell surface heparan sulphate proteoglycan, which binds to the extracellular matrix (ECM), growth factors and antithrombin III. The early expression of syndecan-1 during mouse embryonic development suggests a potential role in the communication between the embryo and the ECM of decidua. Using immunohistochemical methods, the present study showed that the expression of syndecan-1 in the trophoblast cells changes along trophoblast differentiation. The syncytiotrophoblasts in the chorionic villi exhibited an apical expression of syndecan-1. This suggests that the expression is restricted to non-migrating, non-proliferating trophoblasts. The mode of syndecan-1 expression by human placental trophoblasts is independent of gestational age. The expression is not changed in miscarriages. In pre-eclampsia, the staining for syndecan-1 on the villous syncytiotrophoblast is weaker compared to normal pregnancy, but in placental bed the expression is similar. The unique apical localization of syndecan-1 in chorionic villi, not detected in any other tissues, suggests a potential role in fetomaternal communication probably via growth factor binding and in anticoagulation of intervillous circulation.

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Citations

Mar 28, 2009·The Journal of Reproduction and Development·Jumpei TerakawaYasuo Kiso
Jun 1, 2011·American Journal of Reproductive Immunology : AJRI·Golla Jaya PrakashSatish Kumar Gupta
Dec 20, 2000·American Journal of Obstetrics and Gynecology·V I JokimaaL Anttila
Mar 18, 2015·Journal of Reproductive Immunology·Sarah J Boeddeker, Alexandra P Hess
Dec 6, 2011·The American Journal of Pathology·Amy ChuiJoanne M Said
Nov 23, 2006·Fertility and Sterility·Tsung-Hsuan LaiYulian Zhao
Jun 15, 2016·PloS One·Robin E GandleyCarl A Hubel
Sep 4, 2007·Seminars in Cell & Developmental Biology·Catherine B Kirn-SafranDaniel D Carson
Jun 29, 2013·Virchows Archiv : an International Journal of Pathology·Szilvia SzaboNandor Gabor Than
Oct 18, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Lorenz KuesselHarald Zeisler
Feb 13, 2020·Reproductive Sciences·Elizabeth T GreeleyChristine N Metz
Jun 2, 2020·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Kate BramhamLucy C Chappell
Jul 31, 2020·Human Reproduction Update·Shingo IoAnd Shigehito Yamada
Apr 25, 2020·American Journal of Reproductive Immunology : AJRI·Yanhong XuLijun Ding
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Atis MuehlenbachsPatrick E Duffy
Apr 9, 2021·Cell Stem Cell·Shingo IoYasuhiro Takashima
Dec 17, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Samantha L MarguliesVinita Parkash
Jul 8, 2021·Reproductive Sciences·Chao LiuHuijie Gao

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