Expression of systemic protection and delayed-type hypersensitivity to Listeria monocytogenes is mediated by different T-cell subsets.

Infection and Immunity
J R BaldridgeD J Hinrichs

Abstract

The relationship between acquired cellular resistance and delayed-type hypersensitivity (DTH) during the immune response to Listeria monocytogenes was investigated. Treatment of concanavalin A-stimulated Listeria-immune spleen cells with anti-CD8 antibody plus complement abrogated the adoptive transfer of systemic antilisterial immunity but had no effect on the transfer of DTH. In contrast, in vitro depletion of the CD4+ T-cell subset eliminated the ability of culture-activated cells to transfer DTH reactivity but did not interfere with the adoptive transfer of protection. In vivo, the infusion of anti-CD8 antibody inhibited the expression of both actively and adoptively transferred protection but did not influence the development of DTH skin test reactivity to L. monocytogenes antigens. In vivo depletion of the CD4+ T-cell subset eradicated the DTH response, with only minor influence of the protective anti-Listeria response. The apparent functional dissociation of the CD4+ (DTH) and CD8+ (protection) T-cell populations was further emphasized by our findings that the adoptive transfer of protection was dependent on a cyclophosphamide-sensitive cell population, whereas DTH reactivity was mediated by a cyclophosphamide-resistant ...Continue Reading

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Citations

Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M S SeamanJ Forman
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D KeilS B Pruett
Nov 26, 2002·International Journal of Cancer. Journal International Du Cancer·Chih-Wei LinShow-Li Chen
Aug 1, 1997·Immunological Reviews·R J NorthJ W Conlan
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Holly StarksH G Archie Bouwer
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Megan J MontfortDavid J Hinrichs
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Britta StrehlUlrich Steinhoff
Nov 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hoonsik ChoChyung-Ru Wang
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mischo KursarHans-Willi Mittrücker
Mar 1, 1993·Infection and Immunity·A D RobertsI M Orme
Feb 1, 1992·Current Opinion in Immunology·D A Portnoy
Aug 26, 1998·Infection and Immunity·E R JensenS H Gregory

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