Oct 7, 1989

Expression of T-cell-receptor beta chain in Reed-Sternberg cells

Lancet
F Dallenbach, Harald Stein

Abstract

Frozen and paraffin sections of biopsy specimens from 65 patients with Hodgkin's disease were immunostained with the monoclonal antibody beta F1, which recognises a formol-resistant framework epitope on the T-cell-receptor beta chain (TCR-beta)--a structure that defines T cells. In 14 patients a subpopulation of Hodgkin and Reed-Sternberg cells showed beta F1 positivity, usually on the surface membrane, in both frozen and paraffin sections. TCR-beta-positive Hodgkin and Reed-Sternberg cells occurred in all types of Hodgkin's disease except the lymphocyte-predominant subtype.

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Mentioned in this Paper

Monoclonal Antibodies
T-Lymphocyte
Reed-Sternberg Cells
Antigenic Specificity
Formol
Histiocytes
Parafilm
Staining and Labeling
T-Cell Receptor
Biopsy

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