Expression of T cell receptor V gamma 5 in the adult thymus of irradiated mice after transplantation with fetal liver cells

European Journal of Immunology
M OgimotoK Nomoto

Abstract

T cell receptor (TcR) gamma/delta displays limited diversity and its diversity is distinct in different stages of ontogeny and in different anatomical sites. The V gamma 5 and V delta 1 gene products are preferentially expressed on the early fetal thymocytes and on Thy-1+ dendritic epidermal cells, whereas the V gamma 4 and V delta 5 gene products are abundantly expressed on the adult thymocytes. To elucidate whether the developmentally ordered appearance of thymocytes expressing TcR gamma/delta is dependent on the source of T cell precursors or is controlled by the thymic environment where T cells develop, we compared the expression of V gamma 5 on the early-appearing thymocytes between irradiated mice after transplantation with fetal liver (FL) cells and those after transplantation with bone marrow (BM) cells. Sequential appearance of thymocyte subpopulations was observed in the thymus of radiation FL chimeras similar to that seen in radiation BM chimeras. A substantial number of thymocytes bearing V gamma 5 appeared in the thymus at the early stage of radiation FL chimeras, whereas few, if any, of such V gamma 5-bearing thymocytes were detected in the thymus at any stage of radiation BM chimeras. These results suggested that...Continue Reading

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Apr 1, 1991·Current Opinion in Immunology·R Scollay
Apr 1, 1992·Current Opinion in Immunology·C Benoist, D Mathis
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