PMID: 11913822Mar 27, 2002Paper

Expression of T helper 1 and T helper 2 cytokine mRNAs in freshly isolated peripheral blood mononuclear cells from dogs with atopic dermatitis

Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine
S HayashiyaY Taura

Abstract

Using reverse transcription-polymerase chain reaction (RT-PCR) and semi-quantitative PCR techniques, mRNA expression for canine interferon (IFN)-gamma, interleukin (IL)-4, IL-5 and IL-10 in freshly isolated peripheral blood mononuclear cells (PBMCs) was examined in dogs with or without atopic dermatitis (AD). The expression of IFN-gamma mRNA in dogs with AD was lower than that in dogs without AD (healthy control). The expression of IL-5 mRNA was higher in dogs with AD than in control dogs, but there were no significant differences in IL-4 mRNA and IL-10 mRNA expression between the groups. The number of circulating eosinophils was higher in dogs with AD than in control dogs, although eosinophilia was found in only one dog with AD. These results suggest that there is a tendency for the PBMCs of atopic dogs to express a type 2 cytokine pattern that is similar to the pattern observed in human AD patients.

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Citations

May 6, 2003·Veterinary Immunology and Immunopathology·A P FosterE J Hall
Sep 15, 2010·Veterinary Immunology and Immunopathology·Sanae ShibataTsuneo Fukata
Jun 12, 2009·The Journal of Investigative Dermatology·Rosanna Marsella, Giampiero Girolomoni
Mar 27, 2009·Veterinary Dermatology·Christine Loewenstein, Ralf S Mueller
Mar 27, 2015·Veterinary Dermatology·Cherie M Pucheu-HastonMelissa N C Eisenschenk
Sep 29, 2004·Veterinary Immunology and Immunopathology·Masayuki ShidaToshiroh Iwasaki
Dec 6, 2005·Veterinary Immunology and Immunopathology·K WuerschM Welle
Mar 3, 2015·Veterinary Dermatology·Cherie M Pucheu-HastonTim Nuttall
Dec 11, 2013·Veterinary Immunology and Immunopathology·Erin E McCandlessAndrea J Gonzales
Feb 26, 2013·The Veterinary Record·Tim NuttallRichard Halliwell
May 1, 2021·Animals : an Open Access Journal From MDPI·Ana Margarida PereiraAna Rita Jordão Cabrita

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.