Expression of telomerase-associated genes: reflection of telomerase activity in gastric cancer?

World Journal of Surgery
H KameshimaN Watanabe

Abstract

Telomerase activation is a characteristic of immortalized tumor cells but not of normal cells. Telomerase activity has been detected in approximately 85% of malignant tumors, and assaying for telomerase activity is thought to be useful for diagnosing cancer. Three telomerase-associated molecules [human telomerase RNA component (hTR), telomerase-associated protein (TEP1), and human telomerase reverse transcriptase (hTERT)] have been cloned. We semiquantitatively measured telomerase activity and the expression of these genes in cancerous and noncancerous regions of gastric cancer patients. We also investigated whether the expression of these genes correlated with telomerase activity. Telomerase activity in cancerous regions was significantly higher than in noncancerous regions, but there was no correlation between telomerase activity and the expression of these genes. Furthermore, no clear difference was observed between cancerous and noncancerous regions. These data indicate that the level of three telomerase-associated genes (i.e., hTR, TEP1 mRNA, hTERT mRNA), do not reflect telomerase activity, and the RNA levels of these genes are not useful markers for diagnosing gastric cancer.

Citations

Aug 29, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C-P HsuC-Y Chen
Jul 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jinyoung YooChang Suk Kang
Jun 22, 2012·Expert Review of Anticancer Therapy·Daniele CalistriDino Amadori
Jun 1, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoshio TakihanaMasayuki Takeda
Oct 26, 2016·Journal of Human Genetics·Dong-Hao JinJoobae Park
Jan 25, 2003·European Journal of Gastroenterology & Hepatology·Jerzy NowakJacek Wysocki

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