Expression of Ten-m/Odz3 in the fibrous layer of mandibular condylar cartilage during postnatal growth in mice.

Journal of Anatomy
Takashi MurakamiTeruko Takano-Yamamoto

Abstract

It has been speculated that the mandibular condyle develops via the differentiation of the fibroblast-like cells covering the condyle into chondrocytes; however, the developmental mechanisms behind this process have not been revealed. We used laser-capture microdissection and cDNA microarray analysis to elucidate the genes that are highly expressed in these fibroblast-like cells. Among these genes, the transcription of Ten-m/Odz3 was significantly increased in the fibroblast-like cells compared with other cartilage tissues. For the first time, we describe the temporal and spatial expression of Ten-m/Odz3 mRNA in relation to the expression of type I, II, and X collagen mRNA, as determined by in-situ hybridization in mouse mandibular condylar cartilage and mouse femoral cartilage during the early stages of development. Ten-m/Odz3 was expressed in the fibrous layer and the proliferating and mature chondrocyte layers, which expressed type I and II collagen, respectively, but was not detected in the hypertrophic chondrocyte layer. Furthermore, we evaluated the in-vitro expression of Ten-m/Odz3 using ATDC5 cells, a mouse chondrogenic cell line. Ten-m/Odz3 was expressed during the early stage of the differentiation of mesenchymal cell...Continue Reading

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Citations

Mar 22, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nobuharu SuzukiChihiro Akazawa
Sep 20, 2017·PloS One·K R Torres-da-SilvaC A Casatti
Oct 3, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·George FeldmanJavad Parvizi
Aug 23, 2016·Europe's Journal of Psychology·Lucy Amelia James, Claire Louise Fox
Sep 23, 2020·Journal of Cellular Physiology·Ikuko TakanoTeruko Takano-Yamamoto
Jun 22, 2014·The Journal of Bone and Joint Surgery. American Volume·Nobuhito ShibuyaMasahiro Tachi

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