Expression of tenascin, biglycan and decorin in disorders of keratinization

The British Journal of Dermatology
P M SteijlenJ Schalkwijk

Abstract

The distribution of three (recently discovered) extracellular matrix components (tenascin, biglycan and decorin) was studied in normal adult human skin and in a number of monogenic disorders of keratinization, using immunohistology. The expression of tenascin, which is sparsely distributed in normal human dermis, was found to be grossly increased in epidermolytic hyperkeratoses and in Darier's disease. Tenascin expression in three types of ichthyosis (X-linked recessive ichthyosis, autosomal dominant ichthyosis vulgaris, non-erythrodermic lamellar ichthyosis) was similar to that of normal skin. The presence of biglycan and decorin did not show a marked variation between the different disorders studied, suggesting that their expression is subject to regulatory mechanisms distinct from those of tenascin. The increased expression of tenascin in two disorders of keratinization with a hyperproliferative phenotype, lends further support to the hypothesis that dermal tenascin expression is increased as a result of epidermal hyperproliferation.

References

Dec 1, 1992·The British Journal of Dermatology·A A VerstraetenJ Schalkwijk
Sep 1, 1992·Arthritis and Rheumatism·P Witsch-PrehmH Kresse
Jan 1, 1991·The British Journal of Dermatology·J SchalkwijkE J Mackie
Jan 1, 1991·Archives of Dermatological Research·H M van BaarJ Schalkwijk
Feb 1, 1991·Journal of Structural Biology·R FleischmajerJ D Termine
Nov 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P BiancoP G Robey
Sep 20, 1984·Nature·H P Erickson, J L Inglesias
Jan 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A BosseH Kresse

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Citations

May 8, 1999·The British Journal of Dermatology·W FilsellM R Green
Apr 23, 2004·The Journal of Investigative Dermatology·Manon C ZweersJoost Schalkwijk
Jul 2, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Alison M MuirDaniel S Greenspan
Aug 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M LuomanenR P Happonen
Sep 1, 1996·The British Journal of Dermatology·N HunzelmannT Krieg

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