PMID: 7544587Nov 1, 1994Paper

Expression of tenascin during carcinogenesis and involution of hormone-dependent tissues

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
G Vollmer

Abstract

Cytotactin/tenascin/hexabrachion, now referred to as tenascin-C (TN-C), is a hexameric glycoprotein of the extracellular matrix of mesenchymal tissue constituents. A high expression was found in embryonic development and during carcinogenesis of almost all organs. TN-C expression by the mesenchyme thereby appears to be induced by paracrine-acting, epithelial-derived (growth) factors. In normal adult organs there is little, if any, TN-C expression. In the human endometrium for instance, tenascin expression is low in the normal proliferative endometrium and undetectable in the normal secretory endometrium. In this paper, the appearance and expression of TN-C in hormone-dependent tissues, regressing hormone-dependent tissues, and tumors of the endometrium, breast and prostate is reviewed. Further, the regulation of TN-C expression is summarized and possible functions of TN-C during regression and carcinogenesis of hormone-dependent tissues are discussed.

Citations

Jun 12, 1999·The Journal of Pathology·D J HarringtonH J Mardon
Mar 28, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Murat SedeleCanan Figen Sargin
Apr 7, 2005·International Journal of Experimental Pathology·Leon P Bignold
Jan 21, 2004·Biochimica Et Biophysica Acta·Steve MohrBertrand H Rihn
Nov 13, 2004·Cerebral Cortex·Andrey IrintchevMelitta Schachner

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