Expression of testis-specific genes, TEX101 and ODF4, in chronic myeloid leukemia and evaluation of TEX101 immunogenicity.

Annals of Saudi Medicine
S Ghafouri-FardFatemeh Yazarloo

Abstract

Cancer-testis (CT) antigens are a group of antigens with a restricted expression in normal tissues, except testis, and they have aberrant expression in different tumors. This pattern of expression has made them promising targets for immunotherapy and cancer detection. Our aim was to find new members of this group that might be useful as markers in the detection of cancer and immunotherapy. A descriptive study conducted in referral centers of Tehran University of Medical Science from January 2008 to January 2009. We analyzed the expression of two testis-specific genes named ODF4 (outer dense fiber of sperm tails 4) and TEX101 (testis expressed 101) in 20 chronic myeloid leukemia (CML) and 20 normal samples by reverse transcription-polymerase chain reaction and sequencing. Immunogenicity of TEX101 was evaluated by means of enzyme-linked immunosorbent assay. These two genes were expressed in 30% of CML patients but not in any of the healthy donors. Humoral response against TEX101 was not detected in any samples. TEX101 and ODF4 are CT genes useful for detection of CML. Unlike many CT genes, overexpression of TEX101 was not shown to induce immunologic responses in these samples. According to the previous studies, overexpression of ...Continue Reading

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Citations

Dec 4, 2015·Iranian Journal of Cancer Prevention·Soudeh Ghafouri-FardAli Esfandiary
Oct 17, 2017·Immunotherapy·Sepideh Faramarzi, Soudeh Ghafouri-Fard
Apr 29, 2015·Immunotherapy·Ali Esfandiary, Soudeh Ghafouri-Fard
Oct 4, 2017·Immunotherapy·Sepideh Faramarzi, Soudeh Ghafouri-Fard
Feb 24, 2018·Immunotherapy·Mahnaz Seifi-AlanSoudeh Ghafouri-Fard
Feb 5, 2014·Immunotherapy·Soudeh Ghafouri-FardSanaz Tabarestani
Oct 26, 2012·Genetics and Molecular Research : GMR·S Ghafouri-FardM H Modarressi
Oct 27, 2018·Personalized Medicine·Fatemeh YazarlouMohammad H Modarressi
Aug 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Soudeh Ghafouri-Fard
Jul 30, 2019·Human Antibodies·Sepideh Dashti, Zahra Taherian-Esfahani
Apr 10, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Soudeh Ghafouri-Fard
Apr 23, 2019·Human Antibodies·Maliheh AstanehZahra Taherian Esfahani
May 23, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Maryam Beigom MobasheriMohammad Hossein Modarressi
Mar 26, 2019·Human Antibodies·Zahra Taherian-Esfahani, Sepideh Dashti

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Methods Mentioned

BETA
PCR
electrophoresis
enzyme-linked immunosorbent assay
ELISA

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