PMID: 7537359Feb 6, 1995Paper

Expression of tetrodotoxin-resistant sodium channels in capsaicin-sensitive dorsal root ganglion neurons of adult rats

Neuroscience Letters
J B Arbuckle, R J Docherty

Abstract

We have used conventional whole-cell electrophysiological recording techniques to measure the level of expression of tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents in the capsaicin-sensitive and capsaicin-insensitive subpopulations of dorsal root ganglion neurons. We find that there are significantly higher levels of TTX-R expressed in the capsaicin-sensitive group but no difference in the levels of TTX-S. Since capsaicin is a selective stimulant of polymodal nociceptors, these data raise the possibility that TTX-R sodium channels may be an important determinant of nociceptor phenotype.

References

Jan 17, 1992·Brain Research. Developmental Brain Research·N Ogata, H Tatebayashi
Aug 1, 1990·Trends in Pharmacological Sciences·S Bevan, J Szolcsányi
Jan 1, 1989·Annals of the New York Academy of Sciences·H D LuxH Zucker
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Jul 1, 1980·Pflügers Archiv : European journal of physiology·K Görke, F K Pierau

❮ Previous
Next ❯

Citations

Sep 17, 2002·Brain Research·Geon Young LeeJin-Ho Song
Aug 11, 2000·European Journal of Pharmacology·J H SongC S Lee
Mar 29, 2001·Progress in Neurobiology·H Vanegas, H G Schaible
Jan 11, 2003·British Journal of Pharmacology·Masahiro NagahamaJun Sakurai
Mar 1, 1997·International Journal of Urology : Official Journal of the Japanese Urological Association·N Yoshimura, W C de Groat
Dec 1, 1995·British Journal of Pharmacology·M Umemiya, A J Berger
Aug 8, 2001·Japanese Journal of Pharmacology·J KameiS Tanaka
Jun 3, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert WitschiHanns Ulrich Zeilhofer
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·F PorrecaJ C Hunter
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·M S Gold
Jan 9, 2014·Muscle & Nerve·Shinji HirofujiMasashi Neo
Jan 16, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J G de ManP A Pelckmans
Jan 5, 2002·Expert Opinion on Investigational Drugs·J KameiL F Tseng
Sep 24, 1999·Pain·David B Reichling, Jon D Levine
Nov 6, 2004·Journal of Pharmacological Sciences·Junzo KameiNaoya Tamura
Dec 22, 1999·Anesthesiology·P M Dougherty, P S Staats
Jun 6, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kenjiro MatsumotoSyunji Horie
May 2, 2003·British Journal of Pharmacology·Kanako HamadaHitoshi Yasuda
May 23, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Beverley A MooreStephen J Vanner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.