PMID: 8609252Mar 1, 1996Paper

Expression of the adhesion molecules ICAM-1, VCAM-1, and E-selectin and their ligands VLA-4 and LFA-1 in chronic venous leg ulcers

Journal of the American Academy of Dermatology
A WeylJ C Simon

Abstract

Leukocyte binding to endothelial cells (ECs) is thought to contribute to the pathogenesis of leg ulcers caused by chronic venous insufficiency. In other systems, such binding is mediated by the interaction of adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule- (VCAM-1) and E-selectin (on ECs), and leukocyte function-associated antigen-1(LFA-1) and very late activated antigen-4 (VLA-4) (on Leukocytes). Our purpose was to determine whether an increased expression of these adhesion molecules contributes to the pathogenesis of chronic venous insufficiency. Twenty-seven biopsy specimens of inflamed dermatoliposclerotic skin adjacent to venous leg ulcers were stained immunohistochemically with monoclonal antibodies against ICAM-1, VCAM-1, LFA-1, VLA-4, and E-selectin. Staining intensity was compared with that of normal skin. Specimens of leg ulcers caused by chronic venous insufficiency showed increased expression of ICAM-1 and VCAM-1 but not of E-selectin on The expression of LFA-1 and VLA-4 on perivascular leukocytes was increased dramatically in comparison to healthy skin. Upregulation of ICAM-1 and VCAM-1 on ECs may contribute to the increased adherence and extravasation of LFA-...Continue Reading

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Citations

Nov 27, 2004·Archives of Dermatological Research·Hanna GalkowskaUrszula Wojewodzka
Sep 13, 2006·Archives of Dermatological Research·Matthew J MetcalfeGeoffrey Burnstock
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Jun 15, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Hanna GalkowskaWaldemar L Olszewski
Feb 15, 2011·The Journal of Clinical Investigation·Anca SindrilaruKarin Scharffetter-Kochanek
Feb 11, 2011·The Journal of Investigative Dermatology·Yen Chen LiuR Rivkah Isseroff
Mar 14, 2007·Annals of Vascular Surgery·John Alfred Carr, Jae-Sung Cho
Feb 14, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Lachmandath TewarieAres Krishna Menon
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Aug 2, 2016·Biochimica Et Biophysica Acta·Daniela LigiFerdinando Mannello
May 22, 2003·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J DissemondM Goos
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May 4, 2005·The International Journal of Lower Extremity Wounds·Christine UhlemannUwe Wollina

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