PMID: 8944780Nov 1, 1996Paper

Expression of the ADP/ATP carrier and expansion of the mitochondrial (ATP + ADP) pool contribute to postnatal maturation of the rat heart

European Journal of Biochemistry
P SchönfeldR Bohnensack

Abstract

The role of the ADP/ATP carrier (AAC), a key protein of the mitochondrial ATP-generating system, is not clear during postnatal rat heart development. To elucidate this role, the phosphorylating respiration (state 3), the activity and the content of AAC, the size of the exchangeable mitochondrial (ATP + ADP) pool and the control of AAC over respiration at state 3 were measured in mitochondria isolated from rat hearts at various postnatal ages. There was a 5-fold increase in the AAC activity from newborn to aged rat hearts, which was paralleled by a 1.5-fold increase in state 3 respiration. At birth, the AAC and the F0F1-ATP synthase exerted about 80% of the control over phosphorylating respiration (state 3: flux control coefficients 0.39 +/- 0.04 and 0.38 +/- 0.08). The strong increase in the AAC activity was partly caused by the doubling of the protein content. In addition, the turnover number of AAC increased by a factor of 2.5 due to the expansion of the (ATP + ADP) pool from 3.4 +/- 0.9 to 10.6 +/- 1.5 nmol.mg protein-1. The data strongly indicate that the increase in the AAC activity is an essential step in the postnatal maturation of rat heart mitochondria.

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Citations

May 3, 2002·Clinical and Experimental Pharmacology & Physiology·Michael A Portman
May 23, 2007·Pediatric Research·Cynthia MasalungaElsie S Mainali
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Dec 21, 2010·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ling JingYing Sang
Feb 26, 2016·Seminars in Cell & Developmental Biology·Rebecca Ellen KreipkeHannele Ruohola-Baker
Aug 19, 2014·Frontiers in Physiology·Miguel A AonSonia C Cortassa
Dec 12, 2003·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Kok Wah Hew, Kit A Keller
Oct 4, 2018·Biological Chemistry·Sona HubackovaJakub Rohlena
Jan 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Michael A PortmanXue-Han Ning
Jan 24, 2007·Physiological Reviews·Jorgina SatrústeguiAraceli Del Arco
Mar 21, 2019·Canadian Journal of Physiology and Pharmacology·B OstadalF Kolar
Sep 19, 1998·The American Journal of Physiology·J A JenesonH V Westerhoff
Sep 17, 2009·Molecular and Cellular Biochemistry·Marie MilerovaBohuslav Ostadal
Sep 26, 2000·Molecular Genetics and Metabolism·M A Portman

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