Expression of the alpha subunit of human chorionic gonadotropin in normal and neoplastic neuroendocrine cells. An immunohistochemical study.

Acta Pathologica Japonica
Y Tsutsumi

Abstract

The alpha subunit of human chorionic gonadotropin (HCG) was localized Immunohistochemically in paraffin sections of normal human tissues and neuroendocrine tumors. A small subset of dispersed neuroendocrine cells was positive in normal adult tissues, including gastric antrum, urachal remnant, anal glands and prostate. Positive cells were consistently present in perinatal lung but rare in adult lung. In contrast, the beta subunit was absent from these cells. Seventy-two of 151 extrapituitary neuroendocrine tumors (48%) were alpha subunit-positive. Thirty-three of 37 bronchial carcinoids (92%) were immunoreactive, with a high percentage of the tumors (54%) containing moderate to large numbers of positive cells. The alpha subunit was further demonstrated in 9 of 45 small cell lung carcinomas (20%), 19 of 35 extrapulmonary carcinoids (54%), 3 of 11 islet cell tumors (27%) and 8 of 13 medullary thyroid carcinomas (62%). Two of three malignant islet cell tumors were positive. Positive cells were usually few in number, except for two small cell lung carcinomas, two rectal carcinoids, one thymic carcinoid and one malignant islet cell tumor. Pheochromocytomas (n = 10) were negative. Eleven of 19 pulmonary tumorlets (58%) were alpha subu...Continue Reading

References

Jun 1, 1986·The Journal of Clinical Endocrinology and Metabolism·J L JamesonE C Ridgway
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·M FukayamaM Koike
Aug 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M FukayamaH Okumura
May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·A H TashjianS W Rosen
May 1, 1974·The Journal of Clinical Endocrinology and Metabolism·J L Vaitukaitis
May 21, 1981·The New England Journal of Medicine·E C RidgwayN T Zervas
Apr 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D BelletC Bohuon

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Citations

Apr 1, 1997·Microscopy Research and Technique·J R Gosney

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