Expression of the ATF3 gene on cell lines and surgically excised specimens

Oncology Research
T Ishiguro, H Nagawa

Abstract

TI-241 (ATF3 homologue gene) is a metastasis-associated gene that is expressed at higher levels in the high-metastatic mouse B16 melanoma subline B16-FIO than in the low-metastatic clone Fl. We studied ATF3 expression in established cell lines of human colon and stomach cancer and surgically excised human colon cancer. ATF3 was expressed at higher levels in the cell lines that were established from metastatic sites than in those from original tumor sites. Also ATF3 was expressed at higher levels in tumor specimens than in adjacent normal mucosa. especially in the tumors that had invaded the lymphatic ducts and/or the vessels, while there was not a significant relationship hetween its expression and the other pathological features. As metastasis is the most important factor in determining prognosis, these results show the potential for ATF3 in making the prognosis.

Citations

Jul 7, 2012·Journal of Cutaneous Pathology·Crystal L RoseMichael T Tetzlaff
Nov 6, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhen-Feng HaoRong-Ya Yang
Apr 30, 2003·Nature Cell Biology·Laura L SmithJames M Roberts
May 28, 2011·Plastic and Reconstructive Surgery·Adrian DraguRaymund E Horch
May 8, 2007·Nature Clinical Practice. Urology·Emily Willingham, Laurence S Baskin
Nov 25, 2005·Pediatric Research·Benchun LiuLaurence S Baskin
Jun 21, 2013·Archives of Dermatological Research·Jaehoon ChoiTae Hyun Choi

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