PMID: 8971558Dec 1, 1996Paper

Expression of the CD40 antigen on normal endothelial cells and in benign and malignant tumours of vascular origin

Histopathology
J PammerE Tschachler

Abstract

CD40, a member of the nerve growth factor/tumour necrosis factor-receptor family, is expressed on endothelial cells in situ and in tissue culture. It is functionally involved in the regulation of the expression of adhesion molecules in these cells. In the current study we investigated the expression of CD40 on the endothelia of normal fetal and adult human tissues, as well as in the stroma of various neoplasms and in different inflammatory tissue reactions. By immunohistochemistry, endothelia were negative or only weakly positive for CD40 in all normal adult and most fetal organs studied. In contrast, endothelial cells of fetal and embryonic lungs, kidneys and larger vessels consistently expressed the CD40 antigen. Strong expression of CD40 on endothelial cells of blood vessels but not of lymphatic vessels was found in inflammatory reactions. In 65 tumours of vascular origin we found moderate to strong expression of CD40 in all of four juvenile proliferating capillary haemangiomas and 11 lobular capillary haemangiomas of adults. Senile and cavernous haemangiomas as well as lymphangiomas were negative or exhibited only weak CD40 reactivity. Weak to moderate CD40 expression was found in five of eight malignant neoplasms of endoth...Continue Reading

Citations

Dec 14, 1999·Clinical and Experimental Immunology·J FreysdottirF Fortune
Jul 6, 2000·The American Journal of Pathology·J KishimotoR E Burgeson
Apr 10, 1999·Annals of Diagnostic Pathology·P G ChuL M Weiss
Sep 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Thorsten VowinkelD Neil Granger
May 22, 2019·Infection and Immunity·Jose-Andres C PortilloCarlos S Subauste
Feb 1, 2003·European Journal of Gastroenterology & Hepatology·Margareta HolubWalter Reinisch
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eric D HsiMarna B Williams

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