PMID: 18202807Jan 19, 2008Paper

Expression of the cell to cell adhesion molecule, ALCAM, in breast cancer patients and the potential link with skeletal metastasis

Oncology Reports
Simon R DaviesWen G Jiang

Abstract

The activated leukocyte cell adhesion molecule (ALCAM) is involved in cell migration and adhesion. Decreased levels of ALCAM expression in breast cancer tissue are known to correlate with poor prognosis. The current study specifically investigated the ALCAM expression in tumours which developed skeletal metastasis. Fresh frozen primary breast cancer tissues (n=234) and non-neoplastic mammary tissue (n=34) were used. The distribution and location of ALCAM was assessed using immunohistochemical methods and the level of ALCAM was determined using quantitative RT-PCR. The results were analysed against the clinical and pathological data. ALCAM staining was largely membranous and cytoplasmic in normal epithelial cells and is significantly stronger than in cancer cells (p=0.023) and patients who develop skeletal metastasis (p=0.048). The ALCAM transcript levels were lowest in patients with skeletal metastasis (p=0.0048) but were also significantly lower in patients who developed local recurrence (p=0.040) and in those who died from breast cancer (p=0.0075). Patients with moderate and poor prognostic indices have a lower level than those with a good index (p=0.05 and p=0.0089 respectively) and ER-positive tumours show a lower level tha...Continue Reading

Citations

Dec 26, 2015·Biology·Mirka HomrichSimone Diestel
Feb 19, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Solomon F Ofori-Acquah, Judy A King
Mar 27, 2009·International Journal of Cancer. Journal International Du Cancer·Vathany KulasingamEleftherios P Diamandis
Aug 6, 2011·International Wound Journal·Andrew J SandersGirish K Patel
Mar 3, 2011·PloS One·Francesca MiccichèItalia Bongarzone
Jan 10, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Young Ju JeongJin Gu Bong

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