Abstract
The immunohistochemical localization of the complement membrane attack complex (MAC) was examined in Pick disease brain and compared with the distribution of three of its inhibitors, vitronectin, protectin and clusterin. Pick bodies were stained intensely for both the MAC and protectin, weakly for vitronectin, but negatively for clusterin. However, the clusterin antibody intensely stained some pyramidal neurons in affected cortical areas, including ballooned neurons. The present study indicates that a complement-mediated attack is associated with the formation of Pick bodies, and provides further suggestive evidence that clusterin may be a marker for active neuronal degeneration.
References
Oct 1, 1992·Trends in Neurosciences·P C May, C E Finch
May 8, 1992·Brain Research·P L McGeerD G Walker
Dec 1, 1990·Neuron·P C MayC E Finch
Apr 1, 1991·Journal of Neuroimmunology·H AkiyamaP L McGeer
Mar 29, 1991·Brain Research·P L McGeerE G McGeer
Apr 1, 1990·Annals of Neurology·S MurayamaM Tomonaga
May 4, 1990·Neuroscience Letters·T YamadaP L McGeer
Jan 1, 1987·Acta Neuropathologica·J UlrichB His
Dec 1, 1988·The Journal of Clinical Investigation·P XiaW D Geoghegan
Jan 1, 1989·International Immunology·B F MurphyA J d'Apice
Dec 15, 1989·Neuroscience Letters·P L McGeerE G McGeer
Jul 1, 1989·The Journal of Clinical Investigation·M H HolguinC J Parker
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J R DuguidW W Tourtellotte
Jul 1, 1988·Journal of Neuropathology and Experimental Neurology·S LoveR D Terry
May 2, 1986·Science·B L WolozinP Davies
Feb 25, 1983·Journal of Immunological Methods·S Bhakdi, M Muhly
Apr 25, 1994·Neuroscience Letters·O YasuharaP L McGeer
Citations
Jan 1, 1995·Acta Neuropathologica·O YasuharaP L McGeer
Aug 19, 2011·Immunologic Research·Cosmin A TeglaHorea Rus
Sep 1, 1995·Brain Research. Brain Research Reviews·P L McGeer, E G McGeer
Jul 25, 2000·Immunopharmacology·P GasqueB P Morgan
Feb 26, 1998·Immunopharmacology·B P MorganS J Piddlesden
Nov 6, 2002·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Toshinari OdawaraKenji Kosaka
Jan 1, 1997·Microbiology and Immunology·H AkatsuH Okada
Feb 4, 2003·The Journal of Physiology·Dmitry V Vasilyev, Michael E Barish
Aug 21, 2004·The Journal of Physiology·Dmitry V Vasilyev, Michael E Barish
Aug 12, 2008·Neuroscience·T V ArumugamS M Taylor
May 6, 2004·Brain Research·Lee A ShapiroPatricia M Whitaker-Azmitia
Oct 4, 2006·Neuroscience Letters·Hiroyuki MoritaOsamu Yasuhara
Oct 15, 2014·Molecular Neurobiology·Yan LvXiao-Ping Dong
Oct 3, 1999·Experimental Neurology·S K SinghraoP Gasque
Aug 8, 2009·Progress in Brain Research·V Ramaglia, F Baas
Mar 21, 2013·Microscopy Research and Technique·Sim K Singhrao
May 19, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G MehlhornR Schliebs
Aug 11, 2000·Microscopy Research and Technique·M CaleroJ Ghiso
May 1, 1995·The Annals of Pharmacotherapy·R J Oken, P L McGeer
Oct 22, 2002·The Journal of Biological Chemistry·Agueda RostagnoJorge Ghiso
Apr 18, 1998·Brain Pathology·D W Dickson
Oct 1, 1995·Medical Hypotheses·R J Oken