Expression of the CS- and US-pre-exposure effects in the conditioned taste aversion paradigm and their abolition following systemic amphetamine treatment in C57BL6/J mice

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Urs MeyerBenjamin K Yee

Abstract

In classical conditioning, pre-exposures to either the to-be-conditioned stimulus (CS) or unconditioned stimulus (US) can retard subsequent conditioning between the CS and US. The present experiment evaluated the expression of these two pre-exposure effects in mice of the C57BL6/J strain, one of the most common background strains for genetically altered mice. We tested whether their expression would be disrupted by amphetamine treatment (2.5 mg/kg, i.p.) in a conditioned taste aversion paradigm with sucrose as the CS and lithium chloride-induced gastric malaise as the US. We found that one pre-exposure (PE) to either the CS or the US reduced aversion to sucrose solution in the controls following conditioning, but no such tendency was evident in the amphetamine-treated mice. The present study represents the first report of amphetamine-induced disruption of the CS-PE effect (ie latent inhibition) in mice, and the first attempt to compare it directly with the US-PE effect in any species. It extended previous reports in rats and humans, suggesting that the sensitivity of latent inhibition to amphetamine is largely comparable across species, thereby lending credence to the use of the latent inhibition effect as a behavioral assay fo...Continue Reading

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Citations

Dec 17, 2009·Psychopharmacology·Tatiana Lipina, John Roder
Mar 23, 2006·Experimental Brain Research·Urs MeyerBenjamin K Yee
Feb 21, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C Bay-RichterP M Moran
Sep 15, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Segev Barak, Ina Weiner
May 7, 2011·Genes, Brain, and Behavior·S VuillermotU Meyer
Jun 19, 2012·The Journal of Clinical Investigation·Hai-Ying ShenDetlev Boison
Sep 15, 2015·Brain, Behavior, and Immunity·Laura LueckemannManfred Schedlowski
May 26, 2007·Pharmacology, Biochemistry, and Behavior·Catherine M Davis, Anthony L Riley
Oct 27, 2006·Neurobiology of Disease·Kristy J BrunoEllen J Hess
Jun 21, 2005·Neuroscience and Biobehavioral Reviews·Urs MeyerBenjamin K Yee
May 23, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Juliet RichettoUrs Meyer
Jan 8, 2013·Pharmacology, Biochemistry, and Behavior·Philipp SingerBenjamin K Yee
May 3, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Maria Moscoso-CastroOlga Valverde
May 24, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Urs MeyerJoram Feldon

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