Expression of the cyclin-dependent kinase inhibitor p27Kip1 in eutopic endometrium and peritoneal endometriosis

Fertility and Sterility
S MatsuzakiK Okamura

Abstract

This study was undertaken to evaluate the immunohistochemical expression of the cell cycle inhibitor p27Kip1 and proliferation marker Ki67 in peritoneal endometriosis and eutopic endometrium. Prospective study. University hospital. Thirty-one patients with peritoneal endometriosis. During laparoscopy, 25 samples of predominantly red peritoneal lesions and 27 samples of predominantly black peritoneal lesions were collected from 31 patients with endometriosis. Eutopic endometrium from 25 patients with endometriosis was collected by curettage during laparoscopy or just after surgery. The percentage of glandular and stromal cells exhibiting positive staining for p27Kip1 and Ki67 (labeling index, LI) was determined. The LI of stromal cells in red peritoneal lesions for both p27Kip1 and Ki67 was similar to that of proliferative eutopic endometrium. Although the LI of glandular epithelial cells for Ki67 in red lesions was comparable to that of proliferative eutopic endometrium, the LI for p27Kip1 was significantly higher. Furthermore, we detected a significantly higher LI of glandular epithelial and stromal cells for p27Kip1 in black lesions compared with red lesions. Our results suggest that expression of the cyclin kinase inhibitor ...Continue Reading

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Citations

Jun 7, 2013·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Lucy StephensMarie Polley
Jan 15, 2003·Human Reproduction·Sachiko MatsuzakiKunihiro Okamura
Sep 24, 2009·Human Reproduction Update·E Maria C Ohlsson TeagueM Louise Hull
May 29, 2002·Current Opinion in Obstetrics & Gynecology·Michelle Nisolle
Feb 18, 2004·The Journal of Reproduction and Development·Nobuhiko YamauchiKazuyoshi Hashizume
Mar 16, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Rajesh VarmaEamonn R Maher
Sep 8, 2009·Best Practice & Research. Clinical Obstetrics & Gynaecology·Nikos F VlahosStylianos Fotiou
Mar 7, 2008·Fertility and Sterility·Eduardo SchorVilmon de Freitas
Oct 24, 2014·Cell Biochemistry and Function·Hong LiHua Yu
Feb 11, 2015·Archives of Gynecology and Obstetrics·Tae-Hee KimArum Lee
Jan 24, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hiroshi KobayashiHidekazu Oi
Apr 5, 2012·Reproduction in Domestic Animals = Zuchthygiene·N LimanK Gürbulak
Nov 23, 2019·Minerva medica·Bianca BiancoErik Montagna
Oct 29, 2005·Human Reproduction·Masao IzawaNaoki Terakawa
Jun 6, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Cíntia M Camargo-KosugiEduardo Schor

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