Expression of the cyclin kinase inhibitor, p27kip1, in developing and mature human kidney

Kidney International
H L CombsC E Alpers

Abstract

It has been shown that glomerular visceral epithelial cells (VEC) proliferate during glomerulogenesis, but differentiated VEC of the fetal kidney do not. It is also recognized that the proliferative capacity of the VEC in mature kidneys is very limited, and according to some investigators, may be completely absent. The basis for this remains unknown. Cell proliferation is controlled by cell cycle-related proteins, of which one class, the cyclin kinase inhibitors (CKI), cause cell cycle arrest and inhibit proliferation. A role for CKI in kidney development is not known. Accordingly, we examined the expression of the CKI p27kip1 (p27) in developing and mature human kidney tissue. Concomitant expression of markers of cell proliferation, Ki-67-related antigen (Ki-67) and proliferating cell nuclear antigen (PCNA), also were examined in fetal and mature human kidney tissue by immunocytochemical techniques. In developing kidney, Ki-67 and PCNA expression are most pronounced in the nephrogenic zone where expression correlates inversely with increasing glomerular maturation. In well-differentiated glomeruli, Ki-67 and PCNA expression is present in some parietal epithelial cells but is absent in the VEC. In contrast, p27 staining exhibit...Continue Reading

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