Expression of the dengue virus type 2 NS5 protein in a CD4(+) T cell line inhibits HIV replication

The Journal of Infectious Diseases
James H McLindenJ Xiang

Abstract

Human immunodeficiency virus (HIV) load is suppressed during dengue virus infection. The NS5A phosphoprotein of GB virus C (a related flavivirus) inhibits HIV replication in vitro. To determine whether the dengue virus NS5 protein inhibits HIV replication, CD4(+) T cell lines expressing this protein were generated. HIV replication in dengue virus NS5-expressing cells decreased by >90% compared with control cells (P < .01), and this was mediated in part by decreased HIV coreceptor (CXCR4) expression and increased production of SDF-1. Thus, the dengue virus NS5 protein inhibits HIV replication in vitro, potentially explaining the reduction in HIV load observed during acute dengue virus infection.

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Citations

Jan 20, 2009·Current HIV/AIDS Reports·Andrea LiscoLeonid Margolis
Jan 17, 2012·Current HIV/AIDS Reports·Maria Teresa Maidana Giret, Esper Georges Kallas
Jan 31, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Amanda Torrentes-CarvalhoElzinandes Leal de Azeredo
Jul 26, 2011·Vaccine·Jamie Whitehorn, Cameron P Simmons
Nov 30, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Guilherme A CalvetPatrícia Brasil
Nov 18, 2009·Cell Host & Microbe·Andrea LiscoLeonid Margolis
Jan 29, 2014·The American Journal of Tropical Medicine and Hygiene·Uriel A López-LemusFrancisco Espinoza-Gómez
Apr 1, 2015·The American Journal of Tropical Medicine and Hygiene·Junxiong PangYee-Sin Leo
Jul 20, 2017·The American Journal of Tropical Medicine and Hygiene·Francisco Espinoza-GómezUriel A López-Lemus
Nov 20, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jinhua XiangJack T Stapleton

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