Mar 2, 2020

Expression of the endocannabinoid system in the human airway epithelial cells: Impact of sex and chronic respiratory disease status

bioRxiv
Matthew F FantauzziJeremy A Hirota

Abstract

Recreational and medicinal cannabis consumption in the past 12 months has been reported in 1/5th of Canadians, with greater use in males relative to females. Cannabis smoking is the dominant route of delivery in consumers, with the airway epithelium functioning as the site of first contact for inhaled phytocannabinoids. The endocannabinoid system is responsible for mediating the physiological effects of inhaled phytocannabinoids. Acute cannabis smoke inhalation can result in bronchodilation, which may have applications in chronic respiratory disease management. In contrast, chronic cannabis smoke inhalation is associated with reduced lung function and bronchitis, which challenges potential applications in the lung. The contribution of the endocannabinoid system in the airway epithelium to either beneficial or harmful physiological responses remains to be clearly defined in males and females and those with underlying chronic respiratory disease. To begin to address this knowledge gap, a curated dataset of 1090 unique human bronchial brushing gene expression profiles was created from Gene Expression Omnibus deposited microarray datasets. The dataset included 616 healthy subjects, 136 subjects with asthma, and 338 subjects with CO...Continue Reading

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Mentioned in this Paper

In Situ
Receptor, Cannabinoid, CB2
Cannabinoids
Disease Management
Downstream
Pleasurable Emotion
Endocannabinoid Signaling Pathway
Lung
Asthma
Respiratory Conditions due to Smoke Inhalation

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