Expression of the filaggrin gene in umbilical cord blood predicts eczema risk in infancy: A birth cohort study

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Ali H ZiyabWilfried Karmaus

Abstract

Filaggrin gene (FLG) expression, particularly in the skin, has been linked to the development of the skin barrier and is associated with eczema risk. However, knowledge as to whether FLG expression in umbilical cord blood (UCB) is associated with eczema development and prediction is lacking. This study sought to assess whether FLG expression in UCB associates with and predicts the development of eczema in infancy. Infants enrolled in a birth cohort study (n=94) were assessed for eczema at ages 3, 6, and 12 months. Five probes measuring FLG transcripts expression in UCB were available from genomewide gene expression profiling. FLG genetic variants R501X, 2282del4, and S3247X were genotyped. Associations were assessed using Poisson regression with robust variance estimation. Area under the curve (AUC), describing the discriminatory/predictive performance of fitted models, was estimated from logistic regression. Increased level of FLG expression measured by probe A_24_P51322 was associated with reduced risk of eczema during the first year of life (RR=0.60, 95% CI: 0.38-0.95). In contrast, increased level of FLG antisense transcripts measured by probe A_21_P0014075 was associated with increased risk of eczema (RR=2.02, 95% CI: 1.10...Continue Reading

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Citations

Apr 21, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F AmatJ Just
Nov 30, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G RobertsJ A Woodfolk
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Aug 6, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R X Foong, H Brough
Oct 27, 2021·The British Journal of Dermatology·A HoyerC Söderhäll

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