PMID: 8948648Nov 15, 1996Paper

Expression of the gene for the POU domain transcription factor Tst-1/Oct6 is regulated by an estrogen-dependent enhancer

Nucleic Acids Research
K RennerM Wegner

Abstract

Expression of the POU domain protein Tst-1/Oct6 during development of glia and neurons is subject to a tight multifactorial control. Here we show that 17beta-estradiol increases the level of endogenous Tst-1/Oct6 in glial cells. This effect was mediated at the level of gene expression by an enhancer present in the 5' flanking region of the mouse gene for Tst-1/Oct6, approximately 5 kb upstream of the transcriptional start site. The enhancer contained as the functional element a sequence motif that closely resembled a classical estrogen response element. It consisted of an imperfect palindrome with a spacing of 3 bp, and was bound in vitro by activated estrogen receptor. Furthermore, this element was able to confer estrogen responsiveness when introduced into a heterologous promoter. In the Tst-1/Oct6 gene enhancer, a TPA response element was found in close proximity to the estrogen receptor binding site. As a consequence, TPA and estrogen activated transcription of the Tst-1/Oct6 gene in a synergistic manner.

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Citations

Apr 20, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Leslie J Marshall, Eugene O Major
Jun 10, 1998·Nucleic Acids Research·J SchreiberM Wegner
Jun 10, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Noorjahan B JagalurDies Meijer
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·J SchreiberM Wegner
May 4, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Ramzi SeifeddineLiliane Massaad-Massade
Feb 24, 2006·Molecular Reproduction and Development·Manuela MontiMaurizio Zuccotti
Oct 7, 2004·Gene Expression Patterns : GEP·Yuchan ZhouMarie Pantaleon
Jan 24, 2004·Developmental Biology·Hideki YamaguchiMing-Jer Tsai
Mar 10, 2004·International Review of Neurobiology·Maria Ilia
Oct 29, 1998·The Journal of Biological Chemistry·M D DriscollR A Bambara
Jan 24, 1998·The Journal of Biological Chemistry·J SchreiberM Wegner

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