Expression of the genes encoding the rat renal insulin-like growth factor-I system.

Journal of the American Society of Nephrology : JASN
R RabkinN Gillett

Abstract

Insulin-like growth factor-I (IGF-I) modulates renal function, growth, and repair. IGF-I produced in the kidney is one component of the intrarenal IGF-I system comprising the IGF-I receptor (IGF-IR) and six IGF-binding proteins (IGFBP). Because of the physiologic importance of IGF-I and its potential therapeutic properties, the renal sites of mRNA synthesis for IGF-I, IGF-IR, and IGFBP-I through IGFBP-5 were characterized in rat kidney by in situ hybridization. Anatomical heterogeneity was prominent. IGF-I mRNA was present in the thick ascending limb of Henle in the outer medulla, whereas IGF-IR mRNA was diffusely present at low levels throughout the kidney. IGFBP-I mRNA was localized to cells within the distal convoluted tubules as well as the thick ascending limb of Henle. IGFBP-2 mRNA was expressed in glomeruli, medullary ray collecting ducts, pelvic smooth muscle and uroepithelium, and the papilla tip; IGFBP-3 mRNA was localized to the cortical interstitium, whereas IGFBP-4 mRNA was expressed in proximal tubules, medullary ray collecting ducts, and glomeruli. IGFBP-5 was strongly positive throughout the medulla with lesser expression in the distal convoluted tubules and glomeruli. This study highlights the complexity of the...Continue Reading

Citations

Nov 5, 1997·Molecular and Cellular Endocrinology·D J Lindenbergh-KortleveS L Drop
Jan 16, 1999·Journal of the American Society of Nephrology : JASN·F C FervenzaR Rabkin
Jun 9, 2000·Kidney International·N EndlichJ J Helwig
May 29, 2002·Life Sciences·I Ibáñez de CáceresM A Villanúa
Jun 19, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Dieter HaffnerMaren Leifheit-Nestler
May 11, 1999·The Journal of Laboratory and Clinical Medicine·F C FervenzaR Rabkin
Mar 1, 1997·Kidney International·F C FervenzaR Rabkin
Aug 1, 1997·Kidney International·F W HsuR Rabkin
May 9, 1998·Renal Failure·M M FriedlaenderR Rabkin

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