Expression of the glycinergic system during the course of embryonic development in the mouse spinal cord and its co-localization with GABA immunoreactivity

The Journal of Comparative Neurology
Anne-Emilie AllainPascal Branchereau

Abstract

To understand better the role of glycine and gamma-aminobutyric acid (GABA) in the mouse spinal cord during development, we previously described the ontogeny of GABA. Now, we present the ontogeny of glycine-immunoreactive (Gly-ir) somata and fibers, at brachial and lumbar levels, from embryonic day 11.5 (E11.5) to postnatal day 0 (P0). Spinal Gly-ir somata appeared at E12.5 in the ventral horn, with a higher density at the brachial level. They were intermingled with numerous Gly-ir fibers reaching the border of the marginal zone. By E13.5, at the brachial level, the number of Gly-ir perikarya sharply increased throughout the whole ventral horn, whereas the density of fibers declined in the marginal zone. In the dorsal horn, the first Gly-ir somata were then detected. From E13.5 to E16.5, at the brachial level, the density of Gly-ir cells remained stable in the ventral horn, and after E16.5 it decreased to reach a plateau. In the dorsal horn, the density of Gly-ir cells increased, and after E16.5 it remained stable. At the lumbar level, maximum expression was reached at E16.5 in both the ventral and dorsal horn. Finally, the co-localization of glycine and GABA was analyzed, in the ventral motor area, at E13.5, E15.5, and E17.5. ...Continue Reading

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Citations

Jun 25, 2010·Journal of the Association for Research in Otolaryngology : JARO·Jianxun ZhouSusan Shore
Jul 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Stephanie C KochMaria Fitzgerald
Jun 26, 2014·PloS One·Vittorio CaggianoEmilio Bizzi
Mar 6, 2007·Brain Research·Mehdi HossainiJan C Holstege
Oct 28, 2015·Developmental Neurobiology·Anne-Emilie AllainPascal Branchereau
Sep 5, 2009·The Journal of Comparative Neurology·Carlos Ernesto RestrepoOle Kiehn
Mar 28, 2013·Annals of the New York Academy of Sciences·Lea Ziskind-Conhaim
Mar 28, 2013·Annals of the New York Academy of Sciences·Rita BardoniAmy B Macdermott
Jun 12, 2010·Annals of the New York Academy of Sciences·Anne-Emilie AllainPascal Branchereau
Jan 19, 2011·Cellular Reprogramming·Zhi-Yan ShanJing-Ling Shen
Feb 28, 2008·The Journal of Comparative Neurology·Verona Villar-CerviñoMaría Celina Rodicio
Dec 17, 2008·The Journal of Comparative Neurology·Verona Villar-CerviñoMaría Celina Rodicio
Dec 10, 2013·Developmental Neurobiology·Pricila Khan MolyKohei Hatta

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