Abstract
Heat shock protein (HSP) is a molecular chaperone involved in protein folding, assembly, and transport and in the regulation of cell growth and differentiation. HSP27 protein is expressed in murine hair follicle (HF) and in human skin during fetal development. In this investigation we hypothesized that HSP27 protein is expressed in the human scalp skin and its expression in HF changes with the transitions form anagen --> catagen --> telogen stages. To test this hypothesis, the immunoreactivity of HSP27 protein was examined in human scalp skin by immunofluorescent method. A total of 50 normal human scalp skin biopsy specimens were examined (healthy women, age 53-57 years). In each case, 50 HF were analyzed (35, 10, and 5 follicles in anagen, catagen, and telogen, respectively). HSP27 protein expression was prominent in human scalp anagen, and weak in both catagen and telogen HFs. Within HF, HSP27 protein immunoreactivity was prominent in the outer root sheath, inner root sheath, precorteocytes, and corteocytes of the hair shaft. In addition, HSP27 protein expression was prominent in the epidermis, sebaceous glands, sweat glands, and arrector pili muscles. Only some types of heat shock proteins are known to date. Also, our knowle...Continue Reading
References
Jul 26, 1991·Cell·L E Hightower
Jun 1, 1991·Immunological Reviews·S H KaufmannU Steinhoff
Aug 1, 1995·The British Journal of Dermatology·F TrautingerD Metze
Mar 31, 1995·The Journal of Biological Chemistry·G Minowada, W Welch
Jan 1, 1995·Molecular and Cellular Biology·J N LavoieJ Landry
Jul 1, 1993·The Journal of Dermatology·M GhoreishiK Nishioka
Oct 6, 1993·Journal of the National Cancer Institute·D R CioccaS A Fuqua
Aug 1, 1995·Cell Biology and Toxicology·M CharveronY Gall
Sep 1, 1996·Journal of Photochemistry and Photobiology. B, Biology·F TrautingerH Hönigsmann
Aug 1, 1997·International Journal of Dermatology·H HashizumeR Paus
Oct 10, 1998·The British Journal of Dermatology·C JantschitschF Trautinger
Mar 29, 2001·Differentiation; Research in Biological Diversity·S CommoB A Bernard
Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·F Trautinger
Jan 10, 2002·Cell Biology International·Ingela Kindas-MüggeConstanze Riedler
Jun 20, 2002·Clinical and Experimental Dermatology·S D Morris
Oct 9, 2002·Neuron·Susanna C BennClifford J Woolf
Nov 20, 2003·Methods : a Companion to Methods in Enzymology·Pramod Srivastava
Aug 28, 2004·Journal of Cutaneous Pathology·Dilek BayramgürlerNilgün Bilen
Oct 20, 2004·Journal of Cutaneous Pathology·Mahmoud R HusseinMarcelle N Guirguis
Apr 23, 2005·Cancer Biology & Therapy·Mahmoud R HusseinMarcelle N Georgis
Citations
Jul 1, 1994·Journal of Dermatological Science·Y TsujiS Imamura
Jan 17, 2004·Journal of the American Academy of Dermatology·Dany J Touma, Thomas E Rohrer
Mar 31, 2011·Acta Histochemica Et Cytochemica·Au SasakiOsamu Amano
Oct 17, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Harvey B Sarnat, Laura Flores-Sarnat
Sep 1, 2009·Experimental and Molecular Pathology·Mahmoud ShokryMahmoud Rezk A Hussein
Dec 24, 2008·Journal of the American Academy of Dermatology·Mohamed A AdlyMahmoud Rezk A Hussein
Jan 29, 2008·Journal of the American Academy of Dermatology·Mohamed A AdlyRalf Paus
Jan 27, 2015·Fundamental & Clinical Pharmacology·Shaowei LanJin Yu Liu
Nov 6, 2009·Journal of Cutaneous Pathology·Mohamed A AdlyMahmoud Rezk A Hussein
Nov 2, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Cristine DoboCelina Tizuko Fujiyama Oshima
Apr 5, 2012·Ultrastructural Pathology·Ola M Omran, Mostafa Thabet
Apr 4, 2015·European Journal of Pharmacology·Jung-Il KangHee-Kyoung Kang
Nov 18, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jiqing WangYanyu He
Jan 24, 2018·Scientific Reports·Chuen-Yu ChengSan-Yuan Huang
Apr 19, 2007·The Journal of Biological Chemistry·Ryan F L O'ShaughnessyCarolyn Byrne
Apr 8, 2020·Hereditas·Tong ZhouXinsheng Wu
Jun 28, 2008·Journal of Proteome Research·Xiao-Yan HuangJia-Hao Sha
Nov 26, 2020·Cell Reports·Rong FuHuimin Zhang