Expression of the helix-loop-helix genes Id-1 and NSCL-1 during cerebellar development

Developmental Dynamics : an Official Publication of the American Association of Anatomists
M K DuncanK K Chada

Abstract

Neurons throughout the central nervous system (CNS) undergo proliferation, migration, and differentiation during their histogenesis. Although numerous regulatory molecules are expressed in developing neurons, it is unknown whether most of these molecules have the same function throughout the CNS or play different roles in different neuronal populations. Previous studies have shown that Id-1 and NSCL-1 are expressed at high levels in the ventricular and subependymal zones, respectively, of the embryonic brain. In the present study, the expression of Id-1 and NSCL-1 was further investigated during postnatal development of the cerebellum. By Northern blot hybridization analysis, the expression levels of Id-1 and NSCL-1 mRNA were developmentally regulated in the cerebellum, with the highest mRNA levels coinciding with the time of maximal granule cell histogenesis. By in situ hybridization, NSCL-1 mRNA was found in the premigratory zone of the external granule layer (EGL), a structure developmentally analogous to the subependymal zone of the embryonic brain. In normal mice, Id-1 mRNA was found to be transiently expressed in the upper internal granule layer (IGL), a population of cells that recently completed their migration from the...Continue Reading

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Citations

Jun 22, 2002·Molecular and Cellular Biology·Tiziana CogliatiIlan R Kirsch
Jan 11, 2002·Molecular and Cellular Biology·Markus Krüger, Thomas Braun
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eriko FujitaTakashi Momoi
Feb 3, 1999·Annals of the New York Academy of Sciences·E Dicicco-BloomJ Zhang
Jan 31, 2008·Neoplasia : an International Journal for Oncology Research·Enrico De SmaeleAlberto Gulino
Sep 29, 2006·The European Journal of Neuroscience·Marcus KrügerThomas Braun
Aug 9, 2005·Biochemical and Biophysical Research Communications·Hisanobu OdaHiroaki Ohkubo
May 18, 2001·Developmental Biology·J M OlsonS J Tapscott
Feb 9, 2012·Biochemical and Biophysical Research Communications·Woo-Young Kim
Feb 13, 2002·Oncogene·Y Yokota
Jul 4, 2001·Nature Reviews. Neuroscience·V Y Wang, H Y Zoghbi
Jul 9, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C M LiS Z Wang
Dec 15, 2005·The Journal of Biological Chemistry·Yumiko UranoFumio Tashiro
Jul 1, 1998·Brain Research. Molecular Brain Research·M RexP J Scotting

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