Expression of the hepatic endothelin system in human cirrhotic livers

The Journal of Pathology
Yoshihiro IkuraMakiko Ueda

Abstract

It is considered that endothelin-1 participates in the development of liver cirrhosis and it has been recognized that every component of the endothelin system is upregulated in cirrhotic livers. However, the expression pattern of this system, including interaction between its components, is not fully understood in human livers. In this study, the expression pattern of the endothelin system was examined. Immunohistochemical analysis for endothelin-1, endothelin receptors and endothelin-converting enzyme was performed in 16 cirrhotic and 17 normal human liver tissues. Peptides, proteins, and RNAs extracted from the livers were also investigated using quantitative assays for the components of the hepatic endothelin system. Hepatic endothelin-1 levels were significantly higher in cirrhotic livers (0.084 +/- 0.052 pg/mg wet liver) than in normal livers (0.041 +/- 0.032 pg/mg; p < 0.01), and were closely related to the severity of liver fibrosis and portal hypertension. Immunoreactivity for endothelin-1, endothelin receptors, and endothelin-converting enzyme was detected mainly in fibrous areas and in the hepatic vasculature, and was enhanced in cirrhosis. Although there was a negative correlation between the expression of receptor m...Continue Reading

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Citations

Aug 13, 2011·The American Journal of Surgical Pathology·Ryan M GillLinda D Ferrell
Apr 4, 2008·Journal of Clinical Biochemistry and Nutrition·Takehisa SuekaneMakiko Ueda
Feb 17, 2009·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Tian Tian, Lie-Ming Xu
Nov 9, 2005·The Journal of Veterinary Medical Science·Nobutaka YasudaHajime Tsujimoto
Feb 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoshihiro IkuraMakiko Ueda
Mar 16, 2017·Journal of Veterinary Internal Medicine·Y SakamotoT Watari

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