Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis

Glia
Martijn MoransardTobias Suter

Abstract

Hepatocyte growth factor (HGF) is a pleiotropic cytokine able to evoke a wide array of cellular responses including proliferation, migration, and survival through activation of its receptor c-met. Various types of leukocytes have been described to express c-met suggesting that HGF/c-met signaling may directly influence leukocyte responses in inflammation. We have investigated the HGF/c-met pathway in experimental autoimmune encephalomyelitis (EAE), a common mouse model of multiple sclerosis (MS), in which macrophages play a dual role, contributing directly to CNS damage at disease onset but promoting recovery during remission by removing myelin debris. Here we show that during EAE both HGF and c-met are expressed in the CNS and that c-met is activated. We subsequently demonstrate that c-met is primarily expressed in inflammatory lesions by macrophages and a small number of dendritic cells (DCs) and oligodendrocyte progenitor cells (OPCs) but not by microglia or T cells. Complementary in vitro experiments show that only LPS and TNFalpha, but not IL-6, IL-10, or IL-13, are able to induce c-met expression in macrophages. In addition, using TNF signaling deficient macrophages we demonstrate that LPS and TNFalpha induce c-met throug...Continue Reading

References

Apr 1, 1992·Journal of Neuroscience Research·V BocchiniH Kettenmann
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T NakamuraA Ichihara
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·M W MarinoL J Old
Oct 28, 1998·Trends in Cell Biology·C Birchmeier, E Gherardi
Mar 4, 1999·European Journal of Immunology·H P EugsterA Fontana
Mar 16, 2000·International Journal of Experimental Pathology·K A StuartG G Skouteris
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·F GalimiP M Comoglio
Sep 1, 2001·Clinical and Experimental Immunology·Q JiangY Komada
Oct 2, 2001·Scandinavian Journal of Rheumatology·A J FeuerhermA Faxvaag
Apr 23, 2002·Nature Reviews. Neuroscience·Bernhard HemmerHans-Peter Hartung
Jul 9, 2002·Acta Neurologica Scandinavica·Y TsuboiT Yamada
Sep 5, 2002·Nature Reviews. Neuroscience·Robin J M Franklin
Sep 5, 2002·Journal of Neuroscience Research·Henglin Yan, Scott A Rivkees
Jan 25, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K SuzukiY Watanabe
Jan 25, 2003·Brain Research·Kenji ShimazakiTakeshi Kawase
Jul 30, 2003·Cancer Metastasis Reviews·Patrick C MaRavi Salgia
Feb 23, 2005·European Journal of Immunology·Patrice H LaliveAdriano Fontana
Mar 5, 2005·Nature Medicine·Michael Platten, Lawrence Steinman
Apr 27, 2005·Brain Research. Brain Research Reviews·Jerome J A HendriksChristine D Dijkstra
Jun 14, 2005·Trends in Molecular Medicine·Simona CorsoSilvia Giordano
Sep 1, 2005·Molecular and Cellular Biochemistry·Victor Martin Bolanos-Garcia
Jun 15, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Burkhard BecherMelanie Greter
Jul 4, 2007·Journal of Cellular Physiology·Silvia Benvenuti, Paolo M Comoglio
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Fernando Oneissi MartinezMassimo Locati
Oct 22, 2008·Nature Reviews. Neuroscience·Robin J M Franklin, Charles Ffrench-Constant
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·David A Hume
Dec 17, 2008·Annals of the Rheumatic Diseases·H Wekerle
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards

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Citations

May 24, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Arndt ManzelRalf A Linker
Jul 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jea-Hyun BaekThomas Hieronymus
Jul 29, 2017·Frontiers in Cellular and Infection Microbiology·Wolfgang EisenreichWerner Goebel

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